Biotechnologies

COMPLEMENTS OF PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY General objectives The Pharmaceutical Chemistry course is a 5CFU module which aims to provide the student with the basics of the study of medicinal chemistry. The course includes an introductory part in which the importance of medicinal chemistry will be explained, especially its interaction with the other disciplines that the student encounters in the course of studies such as organic chemistry, biochemistry, pharmacology. Since the course is intended for Biotechnology students, traditional medicines and biotechnological medicines will be dealt with; The attention will be focused on the mechanism of action, on the toxicology, as well as on the method of obtaining the drug. Specific goals 1. Knowledge and understanding The student will be able to describe the drug according to all its characteristics: synthesis, metabolism, mechanism of action, metabolism and possible adverse effects. 2. Ability to apply knowledge and understanding At the end of the course, the student will be able to place the drugs in their own class linked to the therapeutic indication. Furthermore, the knowledge of the synthesis or other production method will be essential to allow the student to identify the mechanism of action, the dosage, the active metabolites and to highlight any interactions with other drugs; moreover, the knowledge of the chemical structures of drugs, in the case of synthetic molecules, will allow the student to understand how to design molecules necessary to increase bioavailability or to improve absorption (prodrugs)3. Autonomy of judgment 09:11 The teacher will stimulate students to develop the logical-critical sense by giving interactive lessons, through frequent questions during the lesson, with the aim of inducing them to acquire the ability to connect the various concepts defined in the program, of mastery of the subject. At the end of the course the students will be able to grasp the important points of a scientific publication concerning a new generation drug and plan a research concerning the topics covered in order to broaden their scientific knowledge. This capacity will be tested in the classroom through an exposure of 15-20 minutes of a drug chosen by the student (among the classes treated in classrooms) in which all the points defined during the lessons must have been developed. The exhibition will then be the subject of discussion between the teacher and the students. 4. Communication skills Through the acquisition of knowledge and understanding, of the ability to apply them and to propose a critical judgment on the topics dealt with, but also through the use of the relative scientific language used by the teacher during the course and the frequent stimulation to the communication of what was learned in lesson, the student will be able to communicate with cognitive and linguistic-perceptive depth with his / her peers and / or belonging to an inherent scientific and social community or of different cultural background. 5. Learning skills The student who has acquired the abilities described above may be able to undertake future studies in a more autonomous, self-managed and rapid manner, but also to propose thematic social and / or work contexts useful to the scientific progress of society in the field of human health.