Digital Epidemiology and Precision Medicine

Course objectives

General objectives. Digital data sources and digital traces of human behaviour have the potential to provide local and timely information about disease and health dynamics at the population level. The general aim of the course is to introduce students to the analysis of epidemiological and omics data and to the use of computational approaches for medical/clinical purposes. Specific objectives. The course consists of two modules. The first module will deal with the opportunities and challenges of mining digital data sources for epidemiological and public health signals and will provide an overview of the state of the art of this emerging field. The second module will focus on “precision medicine”, an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. With the second module, the students are expected to acquire basic biology knowledge and skills and to become familiar with the analysis and integration of omics data. Knowledge and understanding. The course will include theory and hands-on lectures. Students will be trained in the basic theory for the identification of gene interactions and in the use of network science. Apply knowledge and understanding. At the end of the course students will have become familiar with basic biological concepts, with the analysis of omics and epidemiological data and with the use of networks for the investigation of infectious disease dynamics and disease etiology, diagnosis, and treatment. Critical and judgment skills. At the end of the course, students will be able to critically analyse the results of their analysis. Communication skills. The students will be required to produce reports describing hands-on projects with specific sections for the description of the obtained results and their discussion. Learning ability. The projects will be developed in small groups encouraging team building.

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MANUELA PETTI Lecturers' profile

Program - Frequency - Exams

Course program
- Course intro - Basic concepts in network science - Introduction to Precision Medicine - Essentials of Molecular Biology - Transcriptomics - Gene regulatory networks and gene co-expression networks - Patients stratification - Introduction to Digital Epidemiology: Big data and Data Science - Mathematical models for infectious diseases (compartmental models) - Epidemic processes on networks, epidemic threshold, reproductive number - Hands-on lecture: Biological networks, Network Epidemiology - Seminar: Data science and digital traces for innovation in public health
Prerequisites
No prerequisites required
Books
- Bruce Alberts, Dennis Bray, Karen Hopkin, Essential Cell Biology, WW Norton & Co - Joseph DiStefano, Dynamic Systems Biology Modeling and Simulation, Academic Press, 2013 - A.-L. Barabási, “Network Science”, Cambridge University Press Other teaching material in electronic format (slides, code) will be distributed by the teacher
Frequency
Attendance recommended, but not mandatory
Exam mode
The evaluation will take place with the execution and discussion of a project and with an oral test on the theory.
Lesson mode
The course includes theoretical and hand-on lectures and seminars
  • Lesson code10593053
  • Academic year2025/2026
  • CourseData Science
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDING-INF/06
  • CFU6