Notizie
Anno Accademico 2024/2025
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Le lezioni cominceranno il 26 Settembre 2024
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Orari di ricevimento
Lunedì-venerdì: si consiglia di prendere un appuntamento via email
Curriculum
29/03/1983: laurea con lode in Chimica all'Università La Sapienza di Roma, relatore il Prof. Pasquale De Santis
1985-1988: Dottorato di Ricerca in Scienze Chimiche (Università La Sapienza di Roma)
1989: ha conseguito il titolo di Dottore di Ricerca in Scienze Chimiche
01/11/1988-30/06/1995: insegnamento nelle Scuole Medie Superiori come docente di ruolo per la classe di concorso Chimica
01/07/1995-31/08/2016: ricercatrice per l’SSD CHEM/02-Chimica Fisica presso il Dipartimento di Chimica dell'Università La Sapienza di Roma
01/09/2016 ad oggi: professore associato per l’SSD CHEM/0-Chimica Fisica presso il dipartimento di Chimica dell'Università La Sapienza di Roma.
2011-2013 e 2013-2016: ha fatto parte del consiglio direttivo della Sezione Lazio della Società Chimica Italiana
2014/2015 e 2016/2017: Riconoscimento di Eccellente Insegnamento Universitario da parte della Facoltà di Scienze Matematiche Fisiche e Naturali
È stata co-chair del Comitato Organizzatore e del Comitato Scientifico del XLVII Congresso Nazionale della Divisione della Chimica Fisica (Roma, 1-4/7/2019).
Ha fatto parte del Comitato Organizzatore del SILS Conference 2023 che si terrà a Roma (30/8-1/9//2023).
1/11/2019-31/10/2022: è stata presidente del Consiglio di Area Didattica Scienze Chimiche (Sapienza)
E’ reviewer delle riviste internazionali: Biophysical Journal, BMC Genomics, alcune riviste IOP Sciences (Nanotechnology, Physical Biology, Molecules, Journal of Physics: Condensed Matter), Interface Focus (Royal Society Publishing), Langmuir, Organic Letters, Chemical Physics Letters, Electrophoresis, DNA Research, Supramolecular Chemistry e Biophysical Chemistry, ACS Applied Materials Interfaces, Advanced Materials Interfaces e Advanced Materials, Advanced Materials, Nature Communication.
E’ stata referee esterno dell’European Research Council per ERC junior e The Netherlands Organisation for Scientific Research (NWO).
Indici Bibliometrici: 1190 citazioni, HI 18
Attività di ricerca
I suoi principali interessi di ricerca sono rivolti allo studio delle proprietà chimico-fisiche di ibridi a base peptidica con proprietà di associazione spontanea (coniugati peptide-polimero, lipopeptidi, derivati sale biliare-peptide, peptide-carbon dots) per applicazioni in nanomedicina. Di recente è coinvolta in un progetto incentrato sui coniugati a base peptidica con attività antimicrobica. Ha partecipato al progetto di Ricerca di Ateneo (Sapienza) “Bile acids-based macromolecular antimicrobials for biomedical applications”, 2022, Progetto PRIN 2022 Finanziato dall’Unione europea – Next generation EU 2022HSFEPY - Biomimetic antimicrobial vesicle-like nanoarchitectures for multi- drug-resistant bacteria-BELIEVE e a Rome Technopole, Flagship 7 " Advanced and automated innovation labs for diagnostic and therapeutic biopharma solutions", 2023. E’ responsabile del Progetto per intervento di ammodernamento do attrezzature scientifiche dipartimentali “Laboratorio di TEcniche AvanzaTe di Interazione radiazione MatEria (TeaTime)”, 2023
PUBBLICAZIONI
74. V. D’Annibale, L. Ariodante, C. Marconi, L, Piccirillo, P. Jönsson, A. D’Annibale, D. Monti, A, Scipioni, K. Schillén, L. Galantini, M. Fornasier, Tuning structure and morphology of lipidic cubosomes by encapsulation of novel porphyrin-derivatives.
Colloids and Surface Interfaces Biointerfaces, 262 (2025) 114646.
73. E. Lucci, L. Antonelli, M. Gherardi, C. Fanali, S. Fanali, A. Scipioni, P. Lupattelli, A. Gentili, B. Chankvetadze, A liquid chromatography-mass spectrometry method for the enantioselective multiresidue determination of nine chiral agrochemicals in urine using an enrichment procedure based on graphitized carbon black.
Analytical, Bioanalytical Chemistry, 416 (2024) 1127-1137.
72. I. Freda, C. Exertier, A. Basile, A. Chaves-Sanjuan, M.V. Vega, M.N. Isupov, N.J. Harmer, P. Swuec, M. Bolognesi, A. Scipioni, C. Savimo, M.L. Di Salvo, R. Contestabile, B. Vallone, A. Tramonti, L. Monteniglio, Structural insights into the DNA recognition mechanism by the bacterial transcription factor , PdxR.
Nucleuc Acids Res., 51 (2023) 8237-8254
71. N. S. Gjerde, A. N. Nardi, C. G. Chen, P. Di Gianvincenzo, M. D’Abramo, A. Scipioni, L. Galantini, S. E. Moya, M. Giustini, Complexation and organization of doxorubicin on polystyrene sulfonate chains: impacts on doxorubicin dimerization and quenching.
Phys. Chem. Che. Phys. 24 (2022) 25990-25998.
70. L. Raganato, A. Del Giudice, A. Ceccucci, F. Sciubba, S. Casciardi, S. Sennato, A. Scipioni, G. Masci, Self-assembling nanowires from a linear L,D-peptide conjugated to the dextran end group.
Int. J. Biol- Macromol. 207 (2022) 656-665.
69. C. G. Chen, M. Giustini, A. Scipioni, A. Amadei, M. D'Abramo, Theoretical modelling of the L-Alanine CD spectrum in water.
Computational and Theoretical Chemistry 1209 (2022) 113591.
68. F. Novelli, A, Strofaldi, S. De Santis, A. Del Giudice, S. Casciardi, L. Galantini, S. Morosetti, N. V. Pavel, G. Masci, A. Scipioni, Polymorphic self-organization of lauroyl peptide in response to pH and concentration.
Langmuir 36 (2020) 3941-3951.
67. S. De Santis, F. Novelli, F. Sciubba, S. Casciardi, S. Sennato, S. Morosetti, A. Scipioni, G. Masci, Switchable length nanotubes from a self-assembling pH and thermosensitive linear L,D-peptide-polymer conjugate.
J. Coll. Interface Science 547 (2019) 256-266.
66. M. Pellegrino, F. Ceccacci, A. Scipioni, S. De Santis, G. Mancini, A. Fierabracci
Exploiting Novel Tailored Immunotherapies of Type 1 Diabetes: Short Interfering RNA Delivered by Cationic Liposomes Enables Efficient Down-Regulation of Variant PTPN22 Gene in T Lymphocytes.
Nanomedicine: Nanotechnology, Biology, and Medicine 18 (2019) 371-379.
65. F. Novelli, S. De Santis, S. Morosetti, M. Titubante, G. Masci, A. Scipioni Peptides with regularly alternating enantiomeric sequence: From ion channel models to bioinspired nanotechnological applications. Peptide Science, e24043 (2018) 1-12.
64. F. Novelli, S. De Santis, M. Diociaiuti, C. Giordano, S: Morosetti, P. Punzi, F. Sciubba,
V. Viali, G. Masci, A. Scipioni
Curcumin loaded nanocarriers obtained by self-assembly of a linear D,L-octapeptidepoly(ethylene glycol) conjugate.
Eur. Polym. J. 98 (2018) 28-38.
63. A. Mollica, G. Macedonio, A. Stefanucci, R. Costante, S. Carradori, V. Cataldi, M. Di
Giulio, L. Cellini, R. Silvestri, C. Giordano, A. Scipioni, P. Punzi, S. Mirzaie
Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity. Lett. in Drug Design and Discovery 15 (2018) 220-226.
62. G. Costanzo, A. Giorgi, A. Scipioni, A. M. Timperio, C. Mancone, M. Tripodi, M.
Kapralov, E. Krasavin, H. Kruse, J. Šponer, J. E. Šponer, S. Pino, E. Di Mauro
Non-Enzymatic Oligomerization of 3',5’ Cyclic CMP and 3',5’ Cyclic GMP under Different Energy Sources Hints at a Non-Fastidious Origin of RNA.
ChemBioChem 18 (2017) 1535-1543.
61. V. Perri, F. Ceccacci, M. Pellegrino, A. Scipioni, S. Petrini, E. Gianchecchi, A. Lorusso,
S. De Santis, G. Mancini, A. Fierabracci
Use of short interfering RNA delivered by cationic liposomes to enable efficient downregulation of ptpn22 gene in human t lymphocytes.
PLoS ONE 12 (2017) e0175784.
60. S. De Santis, R. Chiaraluce, V. Consalvi, F. Novelli, M. Petrosino, P. Punzi, F. Sciubba,
C. Giordano, G. Masci, A. Scipioni
PEGylated b-sheet breaker peptides as inhibitors of b-amyloid fibrillization. ChemPlusChem 82 (2017) 241-250.
59. F. Novelli, S. De Santis, P. Punzi, C. Giordano, A. Scipioni, G. Masci
Self-assembly and drug release study of linear L,D-oligopeptide-poly(ethylene glycol) conjugates.
New Biotechnology 37 (2017), 96-107.
58. F. Ceccacci, A. Scipioni, B. Altieri, L. Giansanti, G. Mancini
Achiral Dye/Surfactant Heteroaggregates for Chiral sensing of Phosphocholines. Chirality 28 (2016) 22-28.
57. C. Pucci, A. Scipioni, M. Diociaiuti, C. La Mesa, L. Perez, R. Pons
Catanionic vesicles and DNA complexes: a strategy towards novel gene delivery systems. RSC Advances 5 (2015) 81168-81175.
56. P. Punzi, S. De Santis, C. Giordano, M. Diociaiuti, F. Novelli, G. Masci, A. Scipioni Bioinspired nanotubes from self-assembly of a linear L,D-oligopeptide-polyethylene glycol) conjugate.
Macromol. Chem. Phys. 216 (2015) 439-449.
55. F. Tardani, P. Strobbia, A. Scipioni, C. La Mesa
Encapsulating carbon nanotubes in aqueous ds-DNA anisotropic phases: Shear orientation and rheological properties.
RSC Advances 3 (2013) 25917-25923.
54. F. Ceccacci, L. Giansanti, G. Mancini, A. Mauceri, A. Scipioni, C. Sperduto Transcription of chirality from molecules to complex systems: The role of hydrophobic interactions.
Supramolecular Chemistry 25 (2013) 741-747.
53. A. Scipioni, P. De Santis
The elastic model in the mechanics of DNA deformations.
Physics of Life Reviews 10 (2013) 82-84.
52. P. De Santis, A. Scipioni
Sequence-dependent collective properties of DNAs and their role in biological systems Physics of Life Reviews 10 (2013) 41-67.
51. S. Aleandri, M. G. Bonicelli, L. Giansanti, C. Giuliani, M. Ierino, G. Mancini, A.
Martino, A. Scipioni
A DSC investigation on the influence of gemini surfactant stereochemistry on the organization of lipoplexes and on their interaction with model membranes Chemistry and Physics of Lipids 165 (2012) 838-844.
50. P. Punzi, C. Giordano, F. Marino, S. Morosetti, P. De Santis, A. Scipioni
Metal chelates anchored to poly-L-peptides and linear D,L-a-peptides with promising nanotechnological applications. Nanotechnology 23 (2012) 395703/1-10
49. G. Costanzo, R. Saladino, G. Botta, A. Giorni, A. Scipioni, E. Di Mauro
Generation of RNA molecules by nonenzymatic base catalyzed polymerization.
ChemBioChem 13 (2012) 999-1008
48. C. Pucci, A. Scipioni, C. La Mesa
Albumin Binding onto Synthetic Vesicles.
Soft Matter 8 (2012) 9669-9675
47. A. Scipioni, P. De Santis
Predicting Nucleosome Positioning in Genomes: Physical and Bioinformatic Approaches.
Biophys. Chem. 155 (2011) 53-64
46. P. De Santis, S. Morosetti, A. Scipioni
Prediction of Nucleosome Positioning in Genomes: Limits and Perspectives of Physical and Bioinformatic Approaches.
J. Biomol. Struct. Dyn. 27 (2010) 743-764.
45. A. Scipioni, S. Morosetti, G. Turchetti, P. De Santis
Geometrical, conformational and topological restraints in regular nucleosome compaction in chromatin.
Biophys. Chem. 148 (2010) 56-67.
44. A. Scipioni, S. Morosetti, P. De Santis
A statistical thermodynamic approach for predicting the sequence dependent nucleosome positioning along genomes. Biopolymers 91 (2009) 1143-1153.
43. P. De Santis, A. Scipioni
A Statistical Thermodynamic Approach for Predicting the Sequence-Dependent Nucleosome Positioning along Genomes.
J. Biomol. Struct. Dyn. 26 (2009) 914-914.
42. A. Scipioni, S. Morosetti, P. De Santis
Geometrical, Conformational, and Topological Restraints in Nucleosome Compaction along Chromatin Fibers.
J. Biomol. Struct. Dyn. 26 (2009) 921-922.
41. P. De Santis, S. Morosetti, A. Scipioni
Peptides with regular enantiomeric sequences: a wide class of modular self-assembling architectures.
J. Nanosci. Nanotechnol. 7 (2007) 2230-2238.
40. C. Letizia, P. Andreozzi, A. Scipioni, C. La Mesa, A. Bonincontro, E. Spigone Protein binding onto surfactant-based synthetic vesicles. J. Phys. Chem. B 111 (2007) 898-908.
39. A. Scipioni, S. Pisano, A. Bergia, M. Savino, B. Samorì, P. De Santis
Recognition on the nanoscale of a DNA sequence by an inorganic crystal surface. Chembiochem 7 (2006) 1645-1648.
38. R. Paparcone, S. Morosetti, A. Scipioni, P. De Santis
A statistical approach for analyzing structural and regulative information in prokaryotic genomes.
Biophys. Chem. 120 (2006) 71-79.
37. B. Samorì, G. Zuccheri, A. Scipioni, P. De Santis
Towards an increase of the hierarchy in the construction of DNA-based nanostructures through the integration of inorganic materials.
Invited in "Nanotechnology: Science and Computation" J. Chen, N. Jonoska and G. Rozemberg Eds. (2006) 215-249, Springer-Verlag Berlin Heidelberg, printed in Germany (ISBN-10 3-540-30295-6).
Source: http://www.springerlink.com/content/r34567n256357n1j/
36. P. De Santis, R. Paparcone, M. Savino, A. Scipioni
Mechanical Properties of Single molecules: a Theoretical Approach.
Invited in "Scanning Probe Microscopies Beyond Imaging. Manipulation of Molecules and Nanostructures" P. Samorì Ed. (2006) 508-533 - Wiley-VCH Verlag, printed in Germany (ISBN-10 3-527-31269-2).
Source: http://onlinelibrary.wiley.com/doi/10.1002/3527608516.ch16/summary
35. C. Anselmi, P. De Santis, A. Scipioni
Nanoscale mechanical and dynamical properties of DNA single molecules. Biophys. Chem. 113 (2005) 209-221.
34. F. Ceccacci, M. Diociaiuti, L. Galantini, G. Mancini, P. Mencarelli, A. Scipioni, C.
Villani
A new simple procedure for discriminating between deracemization and an induced CD effect in chiral recognition experiments on atropoisomers.
Org. Lett. 6 (2004) 1565-1568.
33. A. Scipioni, S. Pisano, C. Anselmi, M. Savino, P. De Santis
Dual role of sequence-dependent DNA curvature in nucleosome stability: the critical test of highly-bent Crithidia fasciculata DNA tract.
Biophys. Chem. 107 (2004) 7-17.
32. C. Anselmi, P. De Santis, R. Paparcone, M. Savino, A. Scipioni A possible role of DNA superstructures in genome evolution. Orig. Life Evol. Biosph. 34 (2004) 143-149.
31. P. De Santis, M. Savino, A. Scipioni, C. Anselmi
DNA sequence-dependent curvature and flexibility in stability and organization of nucleosomes. (
In: "Nucleic Acids: Curvature and Deformation. Recent Advances and New Paradigms" N. C. Stellwagen and U. Mohanty Eds. - ACS Symposium Series 884 – American Chemical
Society - Division of Physical Chemistry (Washington, DC, USA) (2004) 219-231 (ISBN 0-
8412-3862-6 - ISSN: 0097-6156
30. S. Borocci, F. Ceccacci, L. Galantini, G. Mancini, D. Monti, A. Scipioni, A. Venanzi Deracemization of an axially chiral biphenylic derivative as a tool for investigating chiral recognition in self-assemblies.
Chirality 15 (2003) 441-447.
29. N. Besker, C. Anselmi, R. Paparcone, A. Scipioni, M. Savino, P. De Santis Systematic search for compact structures of telomeric nucleosomes. FEBS Lett. 554 (2003) 369-372.
28. A. Scipioni, G. Zuccheri, C. Anselmi, A. Bergia, B. Samorì, P. De Santis
Sequence-dependent DNA dynamics by scanning force microscopy time-resolved imaging. Chemistry and Biology 9 (2002) 1315-1321.
27. B. Sampaolese, A. Bergia, A. Scipioni, G. Zuccheri, M. Savino, B. Samorì, P. De Santis Recognition of the DNA sequence by an inorganic crystal surface. Proc. Natl. Acad. Sci. USA 99 (2002) 13566-13570.
26. G. Zuccheri, A. Bergia, A. Scipioni, P. De Santis, B. Samorì,
DNA on surfaces: Adsorption, equilibration and recognition processes from a microscopist's view
In DNA-based molecular construction book series: AIP Conference Proceedings 640 (2002) 23-37.
25. A. Scipioni, C. Anselmi, G. Zuccheri, B. Samorì, P. De Santis
Sequence-dependent DNA curvature and flexibility from scanning force microscopy images. Biophys. J. 83 (2002) 2408-2418.
24. C. Canzonetta, R. Caneva, M. Savino, A. Scipioni, B. Catalanotti, A. Galeone Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A4T4) and straight (T4A4) DNA sequences.
Biochim. Biophys. Acta -Gene Structures and Expression (attuale Biochim. Biophys. Acta– Gene Regulatory Mechanisms) 1576 (2002) 136-142.
23. C. Anselmi, P. De Santis, R. Paparcone, M. Savino, A. Scipioni From the sequence to the superstructural properties of DNAs.
Biophys. Chem. 95 (2002) 23-47.
22. D. Monti, L. La Monica, A. Scipioni, G. Mancini
Effect of the inclusion of sodium cations on the binding properties of a switchable diporphyrin receptor.
New J. Chem. 25 (2001) 780-782.
21. G. Zuccheri, A. Scipioni, V. Cavalieri, G. Gargiulo, P. De Santis, B. Samorì Mapping the instrinsic curvature and the flexibility along the DNA chain. Proc. Natl. Acad. Sci. USA 98 (2001) 3074-3079.
20. C. Anselmi, G. Bocchinfuso, A. Scipioni, P. De Santis Identification of Protein Domains on Topological Basis.
Biopolymers 58 (2001) 218-229.
19. C. Anselmi, G. Bocchinfuso, P. De Santis, M. Savino, A. Scipioni
A Theoretical Model for the Prediction of Sequence-Dependent Nucleosome Thermodynamic
Stability.
Biophys. J. 79 (2000) 79-91.
18. C. Anselmi, G. Bocchinfuso, P. De Santis, M. Savino, A. Scipioni
Dual Role of DNA Intrinsic Curvature and Flexibility in Determining Nucleosome Stability. J. Mol. Biol. 286 (1999) 1293-1301.
17. C. Anselmi, G. Bocchinfuso, P. De Santis, M. Fuà, M. Savino, A. Scipioni First order elasticity in the superstructural transformations of DNAs. Acta Pharm. 49 (1999) 225-311.
16. C. Anselmi, G. Bocchinfuso, P. De Santis, M. Fuà, A. Scipioni and M. Savino Statistical Thermodynamic Approach for Evaluating the Writhe Transformations in Circular DNAs.
J. Phys. Chem. B 102 (1998) 5704-5714.
15. S. Borocci, M. Erba, G. Mancini, A. Scipioni
Deracemization of an Axial Chiral Biphenylic Structure in Chiral Micellar Aggregates. Langmuir 14 (1998) 1960-1962.
14. P. De Santis, A. Palleschi, A. Scipioni, M. Camalli, R. Spagna, G. Zanotti Conformations of Oligoprolines with Different Configurational Sequences and their Association Complexes with Alkali and Alkali-Earth Ions.
Biopolymers 45 (1998) 257-267
13. G. Benedetti, P. De Santis, S. Morosetti, A. Palleschi, M. Savino, A. Scipioni Superstructural informations in the base sequences of nucleic acids.
Invited in: "Properties and Chemistry of Biomolecular Systems" N. Russo, J.
Anastassopoulou and G. Barone Eds., Kluver Acad. Publ. (1994) 93-108, printed in the Netherlands (ISBN 0-7923-2666-0).
12. P. De Santis, A. Palleschi, M. Savino, A. Scipioni
Theoretical prediction of the gel electrophoretic retardation changes due to point mutations in a tract of Sv40 DNA.
Biophys. Chem. 42 (1992) 147-152.
11. D. Boffelli, P. De Santis, A. Palleschi, A. Scipioni, M. Savino
Theoretical prediction of sequence dependent DNA superstructures and their implications in recognition mechanisms with proteins.
Int. J. of Quantum Chemistry 42 (1992) 1409-1426.
10. P. De Santis, A. Palleschi, M. Savino and A. Scipioni
Theoretical prediction of sequence dependent DNAs superstructures and their implications in recognition mechanisms with proteins. Nucleic Acids Symposium Series (1991) 83-84
(ISSN 0261-3166). Source: http://www.ncbi.nlm.nih.gov/pubmed/1842107
9. P. De Santis, A. Palleschi, M. Savino, A. Scipioni
Validity of the nearest-neighbor approximation in the evaluation of the electrophoretic manifestations of DNA curvature. Biochemistry 29 (1990) 9269-9273.
8. P. De Santis, G. Gallo, A. Palleschi, M. Savino, A. Scipioni A theoretical model of the sequence dependent superstructures of DNA. J. Mol. Liq. 41 (1989) 291-304.
7. P. De Santis, A. Scipioni, A. Palleschi, M. Savino
Structure and stability of Boc(DPro-LPro)2OCH3Na+ complex: a model of Poly(DL-Proline) an alkali ions channel accross membranes.
Biopolymers 28 (1989) 285-296.
6. P. De Santis, A. Palleschi, M. Savino, A. Scipioni A theoretical model of DNA curvature.
Biophys. Chem. 32 (1988) 305-317.
5. P. De Santis, A. Palleschi, M. Savino, A. Scipioni
Poly-(DL-proline), a synthetic polypeptide behaving as ion channel across membranes: conformational studies on ion complexes of the Tetramer Boc (DPro, LPro)2OCH3. J. Phys. Chem. 92 (1988) 4759-4765.
4. P. De Santis, A. Palleschi, S. Morosetti, M. Savino, A. Scipioni
Structural information in deterministic fluctuations of base sequences in DNAs. Theoretical prediction of DNA superstructures.
In "Biological and Artificial Intelligence Systems" (1988) pp. 143-154,
E. Clementi and J. Chin. Editors Publisher: ESCOM Sciente Publishers, Netherlands (ISBN 90-72199-02-2).
3. F. G. Calascibetta, P. De Santis, S. Morosetti, M. Savino, A. Scipioni DNA topology in a chromatin model system.
Cell Biophysics (attuale Cell Biochemistry and Biophysics) 8 (1986) 177-188.
2. P. De Santis, A. Palleschi, M. Savino, A. Scipioni
Channel structures in synthetic polypeptides with alternating configurations. Conformational analysis of poly(DL-proline). Biophys. Chem. 21 (1985) 217-225.
1. P. De Santis, A. Palleschi, M. Savino, A. Scipioni, B. Sesta, A. Verdini
Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes.
Biophys. Chem. 21 (1985) 211-215.