MARIA SAVERIA GILARDINI MONTANI

Le lezioni di Patologia e Fisiopatologia Generale (Basi fisiopatologiche delle malattie) per il corso di Laurea in Infermieristica sede di Anzio, II semestre 2024-25, saranno erogate in presenza nei giorni e orari stabiliti in un'aula dell'edificio di Villa Albani, via Aldobrandini, 32 Anzio. 

 

Le lezioni di Patologia e Fisiopatologia Generale (Basi fisiopatologiche delle malattie) per il corso di Laurea in Ostetricia sede di Viterbo, II semestre 2024-25, saranno erogate in presenza nei giorni e orari stabiliti in un'aula del polo didattico ASL in via Vincenzo Cardarelli 22, Viterbo

 

Le lezioni di Oncologia per il corso di laurea TRMIR, II semestre 2024-25 saranno erogate in presenza nei giorni e orari stabiliti dal CdS.

 

Le lezioni di Patologia Generale per il corso di Laurea in Odontoiatria e protesi dentaria, II semestre 2024-25, saranno erogate in presenza nei giorni e orari stabiliti.

Maria Saveria Gilardini Montani, PhD

Professore II fascia
MEDS-02/A- Patologia Generale
Sapienza Università di Roma
Dipartimento di Medicina Sperimentale
Viale Regina Elena 324 00161 Roma
tel. 0649973310
e-mail: mariasaveria.gilardinimontani@uniroma1.it

2024- Associate Professor MEDS-02/A at the Department of Experimental Medicine, Sapienza University of Rome, Italy

2022-2024 Associate Professor SSD MED04 at the Department of Experimental Medicine, Sapienza University of Rome, Italy

2015-2022 Researcher SSD MED04 at the Department of Experimental Medicine, Sapienza University of Rome, Italy

1995-2015 Researcher SSD MED04 at the Department of Ecology and Biology, Tuscia University, Viterbo, Italy

1993-1995 Fellow of Istituto Superiore di Sanità at the Department of Cellular and Developmental Biology, Sapienza University of Rome, Italy

1992-1993 Fellow of CNR at the Department of Cellular and Developmental Biology, Sapienza University of Rome, Italy

1991-1992 Visiting scientist at the Dept of Biochemistry and Molecular Biology, Harvard University, Cambridge, USA

1988-1992 Fellow of PhD in Experimental Medicine, Sapienza University of Rome, Italy

1987-1988 Fellow of Farmindustria at the Department of Cellular and Developmental Biology, Sapienza University of Rome, Italy

EDUCATION AND TRAINING

1993 PhD degree in Experimental Medicine, Sapienza University, Rome Italy

1988-1992 PhD student in Experimental Medicine Sapienza University Rome, Italy

1989 Abilitazione alla professione di Biologo

1987-1988 Post graduate training at the Department of Cellular and Developmental Biol., Sapienza University, Rome, Italy

1987 Degree in Biological Sciences Sapienza University, Rome, Italy

PERSONAL SKILLS

Mother tongue Italian

Other languages UNDERSTANDING SPEAKING WRITING
Listening Reading Spoken interaction Spoken production
English C2 C1 C2 C1 C1

French B1/2 B1 B2 B1 B1

Organizational / managerial skills Management and organization in the execution of research projects.

Computer skills good command of Microsoft Office™ tool, GraphPad

Publications

1: Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M.
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation,
which prevents its degradation and mitigates DNA damage in colon cancer cells.
Cell Death Discov. 2025 Apr 10;11(1):162. doi: 10.1038/s41420-025-02433-9.

2: Santarelli R, Currà P, Di Crosta M, Gonnella R, Gilardini Montani MS, Cirone M.
Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells.
Molecules. 2025 Jan 16;30(2):335. doi:10.3390/molecules30020335.

3: Gilardini Montani MS, Benedetti R, Cirone M.
Targeting EZH2 in Cancer: Mechanisms, Pathways, and Therapeutic Potential.
Molecules. 2024 Dec 10;29(24):5817. doi: 10.3390/molecules29245817.

4: Di Crosta M, Ragone FC, Benedetti R, D'Orazi G, Gilardini Montani MS, Cirone M.
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21
and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.
Int J Mol Sci. 2024 Jun 27;25(13):7020. doi: 10.3390/ijms25137020.

5: Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, D'Orazi G, Cirone M.
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated
macroautophagy and CMA: impact on mutant TP53 expression.
Autophagy. 2024 Aug;20(8):1854-1867. doi: 10.1080/15548627.2024.2338577.

6: Di Crosta M, Arena A, Benedetti R, Gilardini Montani MS, Cirone M.
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects
of AG490 against Primary Effusion Lymphoma Cells.
Curr Issues Mol Biol. 2024 Mar 14;46(3):2468-2479. doi: 10.3390/cimb46030156.

7: Romeo MA, Focaccetti C, Arena A, Benedetti R, Di Crosta M, Palumbo C,
Gilardini Montani MS, Santarelli R, Gonnella R, D'Orazi G, Bei R, Cirone M.
New insights into the Bortezomib-induced cytotoxic and resistance mechanisms in a
primary effusion lymphoma mouse model.
Hematol Oncol. 2024 Mar;42(2):e3262. doi:10.1002/hon.3262.

8: Gonnella R, Zarrella R, Di Crosta M, Benedetti R, Arena A, Santarelli R,
Gilardini Montani MS, D'Orazi G, Cirone M. HSP110 Inhibition in Primary Effusion
Lymphoma Cells: One Molecule, Many Pro-Survival Targets.
Cancers (Basel). 2023 Nov 29;15(23):5651. doi: 10.3390/cancers15235651.

9: Mardente S, Romeo MA, Asquino A, Po A, Gilardini Montani MS, Cirone M.
HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression.
Viruses. 2023 Oct 19;15(10):2122. doi: 10.3390/v15102122.

10: Arena A, Romeo MA, Po A, Benedetti R, Gilardini Montani MS, Gonnella R,
Santarelli R, Gaeta A, De Smaele E, Cirone M. The inhibition of IRE1alpha/XBP1
axis prevents EBV-driven lymphomagenesis in NSG mice.
Microbiol Spectr. 2023 Dec 12;11(6):e0263623. doi: 10.1128/spectrum.02636-23.

11: Santarelli R, Evangelista L, Pompili C, Lo Presti S, Rossi A, Arena A, Gaeta
A, Gonnella R, Gilardini Montani MS, Cirone M. EBV infection of primary colonic
epithelial cells causes inflammation, DDR and autophagy dysregulation, effects
that may predispose to IBD and carcinogenesis. Virus Res. 2023 Dec;338:199236.
doi: 10.1016/j.virusres.2023.199236. Epub 2023 Oct 12. PMID: 37797746; PMCID:
PMC10582763.

12: Romeo MA, Gilardini Montani MS, Santarelli R, Benedetti R, Arena A, Cirone
M. Acetylation increases expression, interaction with TRAPPC4 and surface
localization of PD-L1. Discov Oncol. 2023 Aug 21;14(1):152. doi:
10.1007/s12672-023-00766-4. PMID: 37603071; PMCID: PMC10442048.

13: Arena A, Di Crosta M, Gonnella R, Zarrella R, Romeo MA, Benedetti R,
Gilardini Montani MS, Santarelli R, D'Orazi G, Cirone M. NFE2L2 and STAT3
Converge on Common Targets to Promote Survival of Primary Lymphoma Cells. Int J
Mol Sci. 2023 Jul 18;24(14):11598. doi: 10.3390/ijms241411598. PMID: 37511362;
PMCID: PMC10380615.

14: Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Santarelli R, Gonnella
R, D'Orazi G, Cirone M. NRF2 and STAT3: friends or foes in carcinogenesis?
Discov Oncol. 2023 Mar 31;14(1):37. doi: 10.1007/s12672-023-00644-z. PMID:
37000324; PMCID: PMC10064365.

15: Gonnella R, Arena A, Zarrella R, Gilardini Montani MS, Santarelli R, Cirone
M. HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary
Effusion Lymphoma Cells. Int J Mol Sci. 2023 Feb 15;24(4):3933. doi:
10.3390/ijms24043933. PMID: 36835344; PMCID: PMC9959463.

16: Arena A, Romeo MA, Focaccetti C, Anastasiadou E, Trivedi P, Cifaldi L,
Gilardini Montani MS, Benedetti R, Santarelli R, Gonnella R, Benvenuto M,
Marchese C, Masuelli L, Bei R, Cirone M. Different outcome of targeting
ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion
lymphoma. Br J Haematol. 2023 Apr;201(2):e12-e15. doi: 10.1111/bjh.18688. Epub
2023 Feb 12. PMID: 36775956.

17: Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M.
JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting
c-Myc and mTOR despite the activation of prosurvival mechanisms. Exp Hematol.
2023 Mar-Apr;119-120:28-41. doi: 10.1016/j.exphem.2022.12.007. Epub 2023 Jan 6.
PMID: 36623719.

18: Romeo MA, Gilardini Montani MS, Arena A, Benedetti R, D'Orazi G, Cirone M.
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the
Mevalonate Pathway. Biomedicines. 2022 Oct 5;10(10):2489. doi:
10.3390/biomedicines10102489. PMID: 36289751; PMCID: PMC9599358.

19: Benedetti R, Arena A, Romeo MA, Gilardini Montani MS, Gonnella R, Santarelli
R, Trivedi P, Cirone M. Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and
PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven
B-Cell Lymphomas. Int J Mol Sci. 2022 Aug 14;23(16):9113. doi:
10.3390/ijms23169113. PMID: 36012375; PMCID: PMC9409055.

20: Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G,
Cirone M. ATF6 prevents DNA damage and cell death in colon cancer cells
undergoing ER stress. Cell Death Discov. 2022 Jun 25;8(1):295. doi:
10.1038/s41420-022-01085-3. PMID: 35752616; PMCID: PMC9233702.

21: Gonnella R, Zarrella R, Santarelli R, Germano CA, Gilardini Montani MS,
Cirone M. Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma
to Dimethyl Fumarate (DMF). Int J Mol Sci. 2022 Jun 17;23(12):6773. doi:
10.3390/ijms23126773. PMID: 35743211; PMCID: PMC9223506.

22: Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M. The
impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers
autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells. Biochem
Biophys Res Commun. 2022 Jul 12;613:19-25. doi: 10.1016/j.bbrc.2022.04.108. Epub
2022 May 3. PMID: 35526484.

23: Arena A, Romeo MA, Benedetti R, Gilardini Montani MS, Cirone M. Targeting
c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple
Myeloma Cells. Biomedicines. 2022 Mar 22;10(4):731. doi:
10.3390/biomedicines10040731. PMID: 35453482; PMCID: PMC9033049.

24: Santarelli R, Pompili C, Gilardini Montani MS, Evangelista L, Gonnella R,
Cirone M. 3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2
and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy
Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells.
Pharmaceutics. 2022 Mar 17;14(3):663. doi: 10.3390/pharmaceutics14030663. PMID:
35336037; PMCID: PMC8948646.

25: Romeo MA, Gilardini Montani MS, Benedetti R, Arena A, Gaeta A, Cirone M. The
dysregulation of autophagy and ER stress induced by HHV-6A infection activates
pro-inflammatory pathways and promotes the release of inflammatory cytokines and
cathepsin S by CNS cells. Virus Res. 2022 May;313:198726. doi:
10.1016/j.virusres.2022.198726. Epub 2022 Mar 4. PMID: 35248672.

26: Romeo MA, Gilardini Montani MS, Benedetti R, Arena A, D'Orazi G, Cirone M.
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1
and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461
PARP Inhibitor. Int J Mol Sci. 2022 Feb 18;23(4):2268. doi:
10.3390/ijms23042268. PMID: 35216385; PMCID: PMC8878079.

27: Gonnella R, Guttieri L, Gilardini Montani MS, Santarelli R, Bassetti E,
D'Orazi G, Cirone M. Zinc Supplementation Enhances the Pro-Death Function of UPR
in Lymphoma Cells Exposed to Radiation. Biology (Basel). 2022 Jan 13;11(1):132.
doi: 10.3390/biology11010132. PMID: 35053130; PMCID: PMC8773084.

28: Gilardini Montani MS, Tarquini G, Santarelli R, Gonnella R, Romeo MA,
Benedetti R, Arena A, Faggioni A, Cirone M. p62/SQSTM1 promotes mitophagy and
activates the NRF2-mediated antioxidant and anti-inflammatory response
restraining EBV-driven B lymphocyte proliferation. Carcinogenesis. 2022 Apr
25;43(3):277-287. doi: 10.1093/carcin/bgab116. PMID: 34958370.

29: Arena A, Romeo MA, Benedetti R, Masuelli L, Bei R, Gilardini Montani MS,
Cirone M. New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer
Effects. Pharmaceuticals (Basel). 2021 Oct 22;14(11):1068. doi:
10.3390/ph14111068. PMID: 34832850; PMCID: PMC8622305.

30: Arena A, Gilardini Montani MS, Romeo MA, Benedetti R, Gaeta A, Cirone M. DNA
damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell
proliferation and Kaposi sarcoma herpesvirus replication. Biochim Biophys Acta
Mol Cell Res. 2022 Jan;1869(1):119168. doi: 10.1016/j.bbamcr.2021.119168. Epub
2021 Oct 30. PMID: 34728235.

31: Romeo MA, Gilardini Montani MS, Benedetti R, Arena A, Maretto M, Bassetti E,
Caiazzo R, D'Orazi G, Cirone M. Anticancer effect of AZD2461 PARP inhibitor
against colon cancer cells carrying wt or dysfunctional p53. Exp Cell Res. 2021
Nov 15;408(2):112879. doi: 10.1016/j.yexcr.2021.112879. Epub 2021 Oct 13. PMID:
34653407.

32: Benedetti R, Gilardini Montani MS, Romeo MA, Arena A, Santarelli R, D'Orazi
G, Cirone M. Role of UPR Sensor Activation in Cell Death-Survival Decision of
Colon Cancer Cells Stressed by DPE Treatment. Biomedicines. 2021 Sep
18;9(9):1262. doi: 10.3390/biomedicines9091262. PMID: 34572447; PMCID:
PMC8466673.

33: Santarelli R, Pompili C, Gilardini Montani MS, Romeo MA, Gonnella R, D'Orazi
G, Cirone M. Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that
blocks the autophagic flux and engages a cross-talk with p53 to activate p21.
IUBMB Life. 2021 Jul;73(7):968-977. doi: 10.1002/iub.2503. Epub 2021 May 21.
PMID: 33987937; PMCID: PMC8361952.

34: Garufi A, Giorno E, Gilardini Montani MS, Pistritto G, Crispini A, Cirone M,
D'Orazi G. P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in
Response to Zn(II)-Curcumin Complex. Biomolecules. 2021 Feb 25;11(3):348. doi:
10.3390/biom11030348. PMID: 33669070; PMCID: PMC7996602.

35: Romeo MA, Gilardini Montani MS, Benedetti R, Arena A, D'Orazi G, Cirone M.
p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation
While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by
wtp53. Biomolecules. 2021 Feb 24;11(3):344. doi: 10.3390/biom11030344. PMID:
33668399; PMCID: PMC7996167.

36: Gilardini Montani MS, Benedetti R, Piconese S, Pulcinelli FM, Timperio AM,
Romeo MA, Masuelli L, Mattei M, Bei R, D'Orazi G, Cirone M. PGE2 Released by
Pancreatic Cancer Cells Undergoing ER Stress Transfers the Stress to DCs
Impairing Their Immune Function. Mol Cancer Ther. 2021 May;20(5):934-945. doi:
10.1158/1535-7163.MCT-20-0699. Epub 2021 Feb 25. PMID: 33632872.

37: Gonnella R, Gilardini Montani MS, Guttieri L, Romeo MA, Santarelli R, Cirone
M. IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by
Promoting Cytokine Release and STAT3 Activation. Biomedicines. 2021 Jan
27;9(2):118. doi: 10.3390/biomedicines9020118. PMID: 33513694; PMCID:
PMC7912693.

38: Romeo MA, Santarelli R, Gilardini Montani MS, Gonnella R, Benedetti R,
Faggioni A, Cirone M. Viral Infection and Autophagy Dysregulation: The Case of
HHV-6, EBV and KSHV. Cells. 2020 Dec 7;9(12):2624. doi: 10.3390/cells9122624.
PMID: 33297368; PMCID: PMC7762304.

39: Romeo MA, Gilardini Montani MS, Benedetti R, Giambelli L, D'Aprile R, Gaeta
A, Faggioni A, Cirone M. The cross-talk between STAT1/STAT3 and ROS up-regulates
PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines
in primary monocytes infected by HHV-6B. Virus Res. 2021 Jan 15;292:198231. doi:
10.1016/j.virusres.2020.198231. Epub 2020 Nov 15. PMID: 33207265.

40: Romeo MA, Gilardini Montani MS, Benedetti R, Santarelli R, D'Orazi G, Cirone
M. STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the
Mevalonate Pathway. Front Oncol. 2020 Jul 10;10:1102. doi:
10.3389/fonc.2020.01102. PMID: 32754441; PMCID: PMC7367154.

41: Garufi A, Baldari S, Pettinari R, Gilardini Montani MS, D'Orazi V, Pistritto
G, Crispini A, Giorno E, Toietta G, Marchetti F, Cirone M, D'Orazi G. A
ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer
cell death/survival outcome according to p53 status. J Exp Clin Cancer Res. 2020
Jun 30;39(1):122. doi: 10.1186/s13046-020-01628-5. PMID: 32605658; PMCID:
PMC7325274.

42: Santarelli R, Arteni AMB, Gilardini Montani MS, Romeo MA, Gaeta A, Gonnella
R, Faggioni A, Cirone M. KSHV dysregulates bulk macroautophagy, mitophagy and
UPR to promote endothelial to mesenchymal transition and CCL2 release, key
events in viral-driven sarcomagenesis. Int J Cancer. 2020 Dec
15;147(12):3500-3510. doi: 10.1002/ijc.33163. Epub 2020 Jul 23. PMID: 32559816.

43: Gilardini Montani MS, Falcinelli L, Santarelli R, Granato M, Romeo MA,
Cecere N, Gonnella R, D'Orazi G, Faggioni A, Cirone M. KSHV infection skews
macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-
regulating pro-tumorigenic cytokine release and PD-L1 expression. Br J Cancer.
2020 Jul;123(2):298-306. doi: 10.1038/s41416-020-0872-0. Epub 2020 May 18. PMID:
32418990; PMCID: PMC7374093.

44: Romeo MA, Gilardini Montani MS, Benedetti R, Garufi A, D'Orazi G, Cirone M.
PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by
Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate
Kinase and Dysregulating UPR. Biomolecules. 2020 Apr 10;10(4):586. doi:
10.3390/biom10040586. PMID: 32290231; PMCID: PMC7226434.

45: Garufi A, Federici G, Gilardini Montani MS, Crispini A, Cirone M, D'Orazi G.
Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant
p53H273 Degradation. Biomolecules. 2020 Mar 3;10(3):392. doi:
10.3390/biom10030392. PMID: 32138264; PMCID: PMC7175121.

46: Romeo MA, Gilardini Montani MS, Gaeta A, D'Orazi G, Faggioni A, Cirone M.
HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid
production and tau phosphorylation in astrocytoma cells as well as in primary
neurons, possible molecular mechanisms linking viral infection to Alzheimer's
disease. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165647. doi:
10.1016/j.bbadis.2019.165647. Epub 2019 Dec 19. PMID: 31866416.

47: Granato M, Gilardini Montani MS, Zompetta C, Santarelli R, Gonnella R, Romeo
MA, D'Orazi G, Faggioni A, Cirone M. Quercetin Interrupts the Positive Feedback
Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing
EBV-Driven B Cell Immortalization. Biomolecules. 2019 Sep 12;9(9):482. doi:
10.3390/biom9090482. PMID: 31547402; PMCID: PMC6769872.

48: Romeo MA, Gilardini Montani MS, Falcinelli L, Gaeta A, Nazzari C, Faggioni
A, Cirone M. HHV-6B reduces autophagy and induces ER stress in primary monocytes
impairing their survival and differentiation into dendritic cells. Virus Res.
2019 Nov;273:197757. doi: 10.1016/j.virusres.2019.197757. Epub 2019 Sep 12.
PMID: 31521763.

49: Garufi A, Traversi G, Gilardini Montani MS, D'Orazi V, Pistritto G, Cirone
M, D'Orazi G. Reduced chemotherapeutic sensitivity in high glucose condition:
implication of antioxidant response. Oncotarget. 2019 Jul 23;10(45):4691-4702.
doi: 10.18632/oncotarget.27087. PMID: 31384396; PMCID: PMC6659798.

50: Gilardini Montani MS, Falcinelli L, Santarelli R, Romeo MA, Granato M,
Faggioni A, Cirone M. Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits
macrophage formation and survival by counteracting Macrophage Colony-Stimulating
Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun
N-terminal kinase (JNK) phosphorylation and autophagy. Int J Biochem Cell Biol.
2019 Sep;114:105560. doi: 10.1016/j.biocel.2019.06.008. Epub 2019 Jun 17. PMID:
31220583.

51: Cirone M, Gilardini Montani MS, Granato M, Garufi A, Faggioni A, D'Orazi G.
Autophagy manipulation as a strategy for efficient anticancer therapies:
possible consequences. J Exp Clin Cancer Res. 2019 Jun 14;38(1):262. doi:
10.1186/s13046-019-1275-z. PMID: 31200739; PMCID: PMC6570888.

52: Gilardini Montani MS, Cecere N, Granato M, Romeo MA, Falcinelli L,
Ciciarelli U, D'Orazi G, Faggioni A, Cirone M. Mutant p53, Stabilized by Its
Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62
that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells. Cancers
(Basel). 2019 May 22;11(5):703. doi: 10.3390/cancers11050703. PMID: 31121848;
PMCID: PMC6562395.

53: Granato M, Gilardini Montani MS, Angiolillo C, D'Orazi G, Faggioni A, Cirone
M. Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by
Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1.
Viruses. 2018 Dec 24;11(1):8. doi: 10.3390/v11010008. PMID: 30586869; PMCID:
PMC6356381.

54: Romeo MA, Masuelli L, Gaeta A, Nazzari C, Granato M, Gilardini Montani MS,
Faggioni A, Cirone M. Impact of HHV-6A and HHV-6B lytic infection on autophagy
and endoplasmic reticulum stress. J Gen Virol. 2019 Jan;100(1):89-98. doi:
10.1099/jgv.0.001176. Epub 2018 Nov 14. PMID: 30427305.

55: Gilardini Montani MS, Santarelli R, Granato M, Gonnella R, Torrisi MR,
Faggioni A, Cirone M. EBV reduces autophagy, intracellular ROS and mitochondria
to impair monocyte survival and differentiation. Autophagy. 2019
Apr;15(4):652-667. doi: 10.1080/15548627.2018.1536530. Epub 2018 Oct 23. PMID:
30324853; PMCID: PMC6526866.

56: Gilardini Montani MS, Santarelli R, Falcinelli L, Gonnella R, Granato M, Di
Renzo L, Cuomo L, Vitillo M, Faggioni A, Cirone M. EBV up-regulates PD-L1 on the
surface of primary monocytes by increasing ROS and activating TLR signaling and
STAT3. J Leukoc Biol. 2018 Oct;104(4):821-832. doi: 10.1002/JLB.2A0118-029RR.
Epub 2018 Jul 24. PMID: 30040158.

57: Granato M, Gilardini Montani MS, Santarelli R, D'Orazi G, Faggioni A, Cirone
M. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance
between pro-apoptotic and pro-survival pathways to induce PEL cell death. J Exp
Clin Cancer Res. 2017 Nov 28;36(1):167. doi: 10.1186/s13046-017-0632-z. PMID:
29179721; PMCID: PMC5704516.

58: Granato M, Romeo MA, Tiano MS, Santarelli R, Gonnella R, Gilardini Montani
MS, Faggioni A, Cirone M. Bortezomib promotes KHSV and EBV lytic cycle by
activating JNK and autophagy. Sci Rep. 2017 Oct 12;7(1):13052. doi:
10.1038/s41598-017-13533-7. PMID: 29026157; PMCID: PMC5638868.

59: Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, D'Orazi
G, Faggioni A, Cirone M. Metformin triggers apoptosis in PEL cells and alters
bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and
inhibiting KSHV lytic cycle activation. Cell Signal. 2017 Dec;40:239-247. doi:
10.1016/j.cellsig.2017.09.020. Epub 2017 Sep 28. PMID: 28964970.

60: Gonnella R, Yadav S, Gilardini Montani MS, Granato M, Santarelli R, Garufi
A, D'Orazi G, Faggioni A, Cirone M. Oxidant species are involved in T/B-mediated
ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle
in PEL cells. Free Radic Biol Med. 2017 Nov;112:327-335. doi:
10.1016/j.freeradbiomed.2017.08.005. Epub 2017 Aug 8. PMID: 28801242.

61: Gilardini Montani MS, Granato M, Santoni C, Del Porto P, Merendino N,
D'Orazi G, Faggioni A, Cirone M. Histone deacetylase inhibitors VPA and TSA
induce apoptosis and autophagy in pancreatic cancer cells. Cell Oncol (Dordr).
2017 Apr;40(2):167-180. doi: 10.1007/s13402-017-0314-z. Epub 2017 Feb 3. PMID:
28160167.

62: Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli
R, Gonnella R, D'Orazi G, Faggioni A, Cirone M. Quercetin induces apoptosis and
autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and
STAT3 signaling pathways. J Nutr Biochem. 2017 Mar;41:124-136. doi:
10.1016/j.jnutbio.2016.12.011. Epub 2017 Jan 5. PMID: 28092744.

63: Santarelli R, Granato M, Pentassuglia G, Lacconi V, Gilardini Montani MS,
Gonnella R, Tafani M, Torrisi MR, Faggioni A, Cirone M. KSHV reduces autophagy
in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin
and ATG5 expression. Autophagy. 2016 Dec;12(12):2311-2325. doi:
10.1080/15548627.2016.1235122. Epub 2016 Oct 7. PMID: 27715410; PMCID:
PMC5173267.

64: Gilardini Montani MS, Granato M, Cuomo L, Valia S, Di Renzo L, D'Orazi G,
Faggioni A, Cirone M. High glucose and hyperglycemic sera from type 2 diabetic
patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin
and p38 MAPK. Biochim Biophys Acta. 2016 Apr;1862(4):805-813. doi:
10.1016/j.bbadis.2016.01.001. Epub 2016 Jan 6. PMID: 26769359.

65: Granato M, Gilardini Montani MS, Filardi M, Faggioni A, Cirone M. Capsaicin
triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced
immune suppression. Oncotarget. 2015 Oct 6;6(30):29543-54. doi:
10.18632/oncotarget.4911. PMID: 26338963; PMCID: PMC4745745.

66: Bernini R, Gilardini Montani MS, Merendino N, Romani A, Velotti F.
Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New
Pharmacological Agents for Cancer Prevention and Therapy. J Med Chem. 2015 Dec
10;58(23):9089-107. doi: 10.1021/acs.jmedchem.5b00669. Epub 2015 Aug 7. PMID:
26225717.

67: Gilardini Montani MS, D'Eliseo D, Cirone M, Di Renzo L, Faggioni A, Santoni
A, Velotti F. Capsaicin-mediated apoptosis of human bladder cancer cells
activates dendritic cells via CD91. Nutrition. 2015 Apr;31(4):578-81. doi:
10.1016/j.nut.2014.05.005. Epub 2014 May 29. PMID: 25220876.

68: Gilardini Montani MS, Prodosmo A, Stagni V, Merli D, Monteonofrio L, Gatti
V, Gentileschi MP, Barilà D, Soddu S. ATM-depletion in breast cancer cells
confers sensitivity to PARP inhibition. J Exp Clin Cancer Res. 2013 Nov
19;32(1):95. doi: 10.1186/1756-9966-32-95. PMID: 24252502; PMCID: PMC4176289.

69: Natoni F, Diolordi L, Santoni C, Gilardini Montani MS. Sodium butyrate
sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic
apoptotic pathways. Biochim Biophys Acta. 2005 Sep 30;1745(3):318-29. doi:
10.1016/j.bbamcr.2005.07.003. PMID: 16109447.

70: Somma F, Tuosto L, Gilardini Montani MS, Di Somma MM, Cundari E, Piccolella
E. Engagement of CD4 before TCR triggering regulates both Bax- and Fas
(CD95)-mediated apoptosis. J Immunol. 2000 May 15;164(10):5078-87. doi:
10.4049/jimmunol.164.10.5078. PMID: 10799864.

71: Di Somma MM, Somma F, Gilardini Montani MS, Mangiacasale R, Cundari E,
Piccolella E. TCR engagement regulates differential responsiveness of human
memory T cells to Fas (CD95)-mediated apoptosis. J Immunol. 1999 Apr
1;162(7):3851-8. PMID: 10201902.

72: Gilardini Montani MS, Tuosto L, Giliberti R, Stefanini L, Cundari E,
Piccolella E. Dexamethasone induces apoptosis in human T cell clones expressing
low levels of Bcl-2. Cell Death Differ. 1999 Jan;6(1):79-86. doi:
10.1038/sj.cdd.4400461. PMID: 10200551.

73: Hargreaves RG, Borthwick NJ, Gilardini Montani MS, Piccolella E, Carmichael
P, Lechler RI, Akbar AN, Lombardi G. Dissociation of T cell anergy from
apoptosis by blockade of Fas/Apo-1 (CD95) signaling. J Immunol. 1997 Apr
1;158(7):3099-107. PMID: 9120262.

74: Piazza C, Gilardini Montani MS, Moretti S, Cundari E, Piccolella E. Cutting
edge: CD4+ T cells kill CD8+ T cells via Fas/Fas ligand-mediated apoptosis. J
Immunol. 1997 Feb 15;158(4):1503-6. PMID: 9029083.

75: Hargreaves RG, Borthwick NJ, Gilardini Montani MS, Piccolella E, Carmichael
P, Lechler RI, Akbar AN, Lombardi G. Induction of apoptosis following antigen
presentation by T cells: anergy and apoptosis are two separate phenomena.
Transplant Proc. 1997 Feb-Mar;29(1-2):1102-4. doi:
10.1016/s0041-1345(96)00433-2. Erratum in: Transplant Proc. 2006 Jun;38(5):1641.
Montani, MS [corrected to Gilardini Montani, MS]. PMID: 9123219.

76: Tuosto L, Gilardini Montani MS, Lorenzetti S, Cundari E, Moretti S, Lombardi
G, Piccolella E. Differential susceptibility to monomeric HIV gp120-mediated
apoptosis in antigen-activated CD4+ T cell populations. Eur J Immunol. 1995
Oct;25(10):2907-16. doi: 10.1002/eji.1830251030. PMID: 7589091.

77: Tuosto L, Cundari E, Gilardini Montani MS, Piccolella E. Analysis of
susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis.
Eur J Immunol. 1994 May;24(5):1061-5. doi: 10.1002/eji.1830240508. PMID:
8181517.

78: Gilardini Montani MS, Tuosto L, Delfini M, Guerritore D, Starace G, Politi
E, Piccolella E. A new tripeptide, Pol 509, influences biochemical events
associated with antigen presentation efficiency of PPD-specific EBV-B cells.
Immunopharmacology. 1993 Jan-Feb;25(1):51-63. doi: 10.1016/0162-3109(93)90030-t.
PMID: 8100558.

79: Di Massimo AM, Gilardini Montani MS, Bardone MR, Moras ML, Malkovsky M,
Antonelli G, Colizzi V. The combined treatment of human peripheral blood
mononuclear cells with thymolymphotropin and interleukin 2 increases PPD-driven
T-cell proliferation and IL-2 induced cellular cytotoxicity against HIV-infected
cells. Int J Immunopharmacol. 1991;13(8):1157-65. doi:
10.1016/0192-0561(91)90167-6. Erratum in: Int J Immunopharmacol. 2006 Dec
20;6(13-14):2069. Gilardini, M S [corrected to Gilardini Montani, M S]. PMID:
1814852.

80: Gilardini Montani MS, Del Gallo F, Gobbi M, Lombardi G, Piccolella E,
Pugliese O, Colizzi V. Regulation of self-major histocompatibility complex
reactive human T-cell clones. Int J Immunopharmacol. 1990;12(3):255-60. doi:
10.1016/0192-0561(90)90080-7. PMID: 1691739.

81: Del Gallo F, Lombardi G, Piccolella E, Gilardini Montani MS, Del Porto P,
Pugliese O, Antonelli G, Colizzi V. Increased autoreactive T cell frequency in
tuberculous patients. Int Arch Allergy Appl Immunol. 1990;91(1):36-42. doi:
10.1159/000235086. PMID: 1690181.

82: Vismara D, Mezzopreti MF, Gilardini Montani MS, Del Porto P, Lombardi G,
Piccolella E, Damiani G, Rappuoli R, Colizzi V. Identification of a
35-kilodalton Mycobacterium tuberculosis protein containing B- and T-cell
epitopes. Infect Immun. 1990 Jan;58(1):245-51. doi:
10.1128/iai.58.1.245-251.1990. Erratum in: Infect Immun. 2006 Apr;74(4):2504.
Gilardini, MS [corrected to Gilardini Montani, Maria Saveria]. PMID: 1688420;
PMCID: PMC258436.

83: Borboni P, Di Cola G, Sesti G, Marini MA, Del Porto P, Gilardini Montani MS,
Lauro R, De Pirro R. Beta-endorphin receptors on cultured and freshly isolated
lymphocytes from normal subjects. Biochem Biophys Res Commun. 1989 Aug
30;163(1):642-8. doi: 10.1016/0006-291x(89)92185-2. PMID: 2550003.

84: Gilardini Montani MS, Del Gallo F, Lombardi G, Del Porto P, Piccolella E,
Arienzo F, Colizzi V. Limiting dilution analysis of T cell unresponsiveness to
mycobacteria in advanced disseminated tuberculosis. Med Microbiol Immunol.
1989;178(5):235-44. doi: 10.1007/BF00191058. PMID: 2506411.

Book Chapter

Gilardini Montani MS. (2007). Apoptosis induction in T lymphocytes by HIV. In: SRIVASTAVA R. Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms. vol. 2, p. 295-311, Humana Press, ISBN/ISSN: 13:978-1-58829-882-9