Curriculum
http://www.farmaciamedicina.uniroma1.it/files/CV/CV_RIMINUCCI_MARA_IT.pdf
POSITION TITLE
Professor, Anatomic Pathology, Department of Molecular Medicine, Sapienza University of Rome
EDUCATION/TRAINING
1997 PhD Human pathology Sapienza University of Rome
1993 Board certified Anatomic pathology, Sapienza University of Rome
1989 MD, Sapienza University of Rome
POSITIONS AND EMPLOYMENT
2016- Professor, Anatomic Pathology, Sapienza University of Rome
2007-2016 Associate Professor, Anatomic Pathology, Sapienza University of Rome
2002-2007 Associate Professor, Anatomic Pathology, University of L’Aquila
1999-2002 Assistant Professor, Anatomic Pathology, University of L’Aquila
1999-2002 (intermittent) Visiting Fellow, Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Bethesda, MD.
1997-1999 Fellowship Fondazione Telethon Italia, University of L’Aquila
1995-1997 Fogarty International Fellowship, Clinical Studies Program, Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Bethesda, MD
CLINICAL POSITIONS
2020- Clinical Program “Advanced diagnostics of skeletal dysplasia” Sapienza University and Policlinico Umberto I University Hospital, Rome
2010- Anatomic Pathology, Sapienza University and Policlinico Umberto I University Hospital, Rome
2002-2003 (intermittent) Expert consultant, Clinical Studies Program – Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Bethesda, MD (National Institutes of Health Clinical Protocols on Fibrous Dysplasia)
OTHER EXPERIENCE AND MEMBERSHIPS
Reviewer
Journal > 50 scientific and medical journals including: Nature, Cell Death and Differentiation, Bone Research, Theranostics, Journal of Clinical Investigation Insight, Stem Cells, Stem Cells Translational Medicine, Journal of Cellular and Molecular Medicine, Bone, American Journal of Pathology, Journal of Dental Research, European Journal of Endocrinology, Journal of Bone and Mineral Research, Calcified Tissue International, others
H1 Connect (Faculty Opinions)
Agencies European Science Foundation, Medical Research Council, Swiss National Science Foundation, European Calcified Tissue Society, French National Research Agency, Czech Science Foundation, Cure Kids, Swiss 3R Competence Centre, Sapienza University Intramural
Editorial Board
2020- Calcified Tissue International; 2016- Stem Cell Research
Scientific Societies
2022-2023 American Society for Bone and Mineral Research- Member; 2017- International Bone Marrow Adiposity Society – Member Boards Alumni
Meeting organization/chair
2017 3rd International Bone Marrow Adiposity 2017, Lausanne, Switzerland; 2023 International FD/MAS Consortium, Silver Spring, MD, USA
HONORS AND AWARDS
2015- Medical Academy of Rome – Academic Member; 2008- H1 Connect (Faculty Opinion) - Invited Faculty Member; 1998 Young Investigator Award-American Society for Bone and Mineral Research; 1998 Travel Award-International Bone and Mineral Society; 1997 Italian Society of Anatomic Pathology; 1996 Young Investigator Award-NIDCR, NIH
INVITED LECTURES, NATIONAL AND INTERNATIONAL (SELECTED)
2024 “Modeling skeletal diseases. Transgenic mice and stem cell based therapeutic approach” University of Rome Tor Vergata, Italy; 2023 FD/MAS Alliance; Fibrous Dysplasia/McCune-Albright Syndrome: Celebrating 25 Years of NIDCR Research, Bethesda, MD, USA; Hot Topics: Malattie dell’osso in età pediatrica. Nuove frontiere diagnostiche e terapeutiche, Rome, Italy; XXIII Congresso Nazionale SIOMMMS, Messina, Italy; 2022 American Society for Bone and Mineral Research Annual Meeting “Fibrous dysplasia of bone” Austin, TX, USA; Workshop: Translational research on bone impairment in rare diseases. “The interest of murine models in evaluating rare bone diseases” Lyon, France; 2021 European Calcified Tissue Society Digital Congress; University of Palermo, Palermo, Italy; 2020 European Calcified Tissue Society Digital Congress, Working Group on Mammalian models; European Calcified Tissue Society Digital Congress, Symposium on Fundamentals and clinical consequences of bone marrow adiposity; 2019 4th FD/MAS Consortium Meeting, Florence, Italy; GISM Annual Meeting, Genova, Italy; 1st National Meeting Metabolic Osteopaty in Pediatric Age, Rome Italy; 2018 28TH Annual Meeting of the Dutch Society for Calcium and Bone Metabolism, Zeist, Netherlands; Winter School of ROAD Network, Paris, France; 2017 VII Convegno Eamas, Arezzo, Italy; Paracelsus, SCI-TReCS, Salzburg; Fibrous Dysplasia Foundation Conference 2017 Silver Spring, MD, USA; International FD/MAS Consortium 3rd Meeting, Leiden, Netherlands; 2016 2nd Bone Marrow Adiposity Meeting, Rotterdam, Netherlands; 29th Annual Conference of Italian Association of Cell Cultures. Crossroads in cellular and molecular biotechnology, L’Aquila, Italy; 2013 11° World Congress International Cartilage Repair Society (ICRS). Izmir, Turkey; HEMO 2013, Brasilia, Brazil; SIOMMMS XII Congresso Nazionale, Bologna, Italy; 2012 Giornata di aggiornamento sul Linfoma di Hodgkin, Rome, Italy; 15° Congresso Immunopathology and orphan diseases. Torino, Italy; 2011 5th Meeting Fibrousdysplasia Ossificans Progressiva, Rome, Italy; Osteotropic cancer: new pathogenetic and clinical aspects, Bari, Italy; Rome Elbow 2011, Rome, Italy; Medicina Rigenerativa: attualità e prospettive, Rome, Italy; Università degli studi di Udine, Udine; Unistem, Rome, Italy; 2010 Convegno Patologia immune e malattie orfane, Torino, Italy; IAP Italian Division, Bologna, Italy; International Meeting on FD/MAS and Cherubism: Best Clinical Practice and Future Research, Bethesda, MD; 2009 Stem cells and wound healing, Turku, Finland; 1st International Conference Regenerative Surgery, Roma, Italy; 2008 Gordon Research Conference "Biomineralization" New London, NH; Accademia Medica, Roma, Italy; 2nd Course in Clinical Dismorphology, Forlì, Italy; 3° Convegno IES, Roma, Italy; Società Italiana di Citometria XXVI Incontro di Aggiornamento e Formazione, Urbino, Italy; 2007 SIMO, Roma Italy; 2005 Meeting on Biological and Clinical Behavior of Fibro-osseous Diseases with Oral Manifestation, Toulouse, France; Congresso Nazionale SIAPEC IAP, Chieti, Italy; Genetics, Biochemistry and Physiology of NDP Kinase NM23 AWD and other metastasis suppressor genes and functions, International Congress, Naples, Italy; 1° Congresso Nazionale SIFC, Roma, Italy; Mediterranean School of Oncology, Roma, Italy; 1st Advances in Rare Bone Diseases Conference, Washington, DC; 2004 Genostem, Tours, France; 2002 IAP Italian Division, Treviso, Italy; VI International Symposium on Adesive and Reconstructive Dentistry, S. Margherita Ligure, Italy; 2000 European Pediatric Orthopedic Society, Milan, Italy; Gordon Research Conference “Matrix Metalloproteases”, Il Ciocco, Italy; 1997 Gordon Research Conference, Cellular and Molecular Biology of Bones and Teeth, Meriden, NH.
WEBINARS
2025 FD/MAS Research update “Investigating key clinical aspects of Fibrous dysplasia of bone in a transgenic mouse model (EF1a- GsaR201C mice) of the disease: pain, effect of anti-resorptive treatments and “rebound” phenomenon”; 2024 Care4Bones “Targeting bone resorption in Fibrous dysplasia of bone: insights from mouse models”; 2023 FD/MAS Research update “Osteoclasts and pain in Fibrous Dysplasia: investigating and targeting the molecular links in a transgenic mouse model (EF1-GsR201C mice) of human Fibrous Dysplasia”; 2021 FD/MAS Research update “Anti-resorptive drugs in Fibrous Dysplasia of bone: studies on the
effects of a RANKL inhibitor and Zoledronic Acid in a murine model of the disease by radiography, histology and genome-wide gene expression analysis (NanoString)”; 2019 Stem Cell Technologies Webinars “Bone marrow skeletal progenitors and bone diseases”
COMMENTARIES ON PUBLISHED WORK
1. Singer FR: Commentary: Fibrous dysplasia of bone: the bone lesion unmasked. Am J Pathol 151: 1511 1515,1997; 2. Olsen BR: Editorial: "A rare disorder, yes. An unimportant one, never" J Clin Invest 101: 1545-1546, 1998; 3. Quarles LD: Commentary: “Evidence for a bone-kidney axis regulating phosphate Homeostasis”. J Clin Invest 112: 642-646, 2003; 4. Janet T. Powell and Toste Länne "Through Thick and Thin Collagen Fibrils, Stress, and Aortic Rupture: Another Piece in the Jigsaw". Circulation 2007 115: 2687 - 2688, doi:10.1161/CIRCULATIONAHA.107.709139; 5. J Clin Invest 101(8), 1998- Cover Story; 6. National Institutes of Health - Press release April 14, 1998; 7. OMIM #174800 MCCUNE-ALBRIGHT SYNDROME, MAS; #139320 GNAS COMPLEX LOCUS, GNAS; #166260 GNATHODIAPHYSEAL DYSPLASIA, GGD; #166250 OSTEOGLOPHONIC DYSPLASIA, OGD; #136350 FIBROBLAST GROWTH FACTOR RECEPTOR1 FGFR1; 8. De Castro LF, Boyce AM, Collins MT Editorial: First in Mice: RANKL Neutralization in Fibrous Dysplasia. J Bone Miner Res 2019 DOI: 10.1002/jbmr.3904.
RESEARCH GRANTS
2023 Italian Government, Department of University and Research – Research Projects of National Interest PRIN (PI); 2023 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2021 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2020 Sapienza University (PI); 2019 Sapienza University (PI); 2019 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2018 Istituto Pasteur-Fondazione Cenci Bolognetti “Seed International Research Projects” (PI); 2018 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2017 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2016 MDBR-Orphan Disease Center University of Pennsylvania (PI); 2015 Telethon (PI); 2015 EC 7th Framework Grant Agreement HEALTH. 2013.1.4-1 (Unit PI); 2015 Sapienza University; 2015 Istituto Pasteur-Fondazione Cenci Bolognetti (PI); 2008 Fondazione Roma (Unit PI); 2008 Italian Government, Department of Health (Unit PI); 2006 Italian Government, Department of University and Research (Unit PI); 2003 Italian Government, Department of University and Research (Unit PI); 2001 Italian Government, Department of University and Research - FIRB
BIBLIOGRAPHY
https://www.scopus.com/authid/detail.uri?authorId=7003835803