Physiotherapy

INTRODUCTION TO CLINICAL BIOCHEMISTRY Laboratory tests; biological samples for analysis, laboratory test purposes. METABOLIC PROFILES OF DIFFERENT ORGANS AND TISSUES Metabolic profiles: brain, heart muscle, liver, muscle, adipose tissue, kidney Tissue/organ interrelationships in response to different physiological (fed/fasting state; stress). Liver as fuel provider for other tissues. Interrelationships between liver and skeletal muscle: Cori cycle and Alanine-Glucose Cycle. Role of hormones in the interactions between tissues and organs. DIABETES MELLITUS Carbohydrate properties and metabolism. Hormone regulation of glucose metabolism: insulin and counter-regulatory hormones. Ketone bodies formation and physiological role. Definition and classification of diabetes mellitus. Diagnostic criteria. Clinical presentation, history, pathogenesis and physiopathology of type 1 and type 2 diabetes. The laboratory for diabetes. Laboratory tests in diagnosis and follow up of patients (monitoring the disease and therapy efficacy): fasting plasma glucose (FPG), self-monitoring of blood glucose, oral glucose tolerance test (OGTT), insulin, C-peptide, glycated haemoglobin (HbA1c). Laboratory tests in acute complications: diagnosis of diabetic ketoacidosis (DKA; hyperglycemic, hyperosmolar non ketotic syndrome. Laboratory tests in chronic complications: lipid profile and microalbuminuria. LIPIDS AND LIPOPROTEIN DISORDERS Lipids properties and metabolism: absorption, transport, storage and metabolism. Lipoproteins: classification, composition, synthesis and metabolism. Role of Apoproteins. Lipoprotein receptors. Lipoprotein electrophoresis and ultracentrifugation Dyslipoproteinemias: definition and classification. Laboratory assessment of lipid metabolism disorders (diagnosis of dyslipidemia and monitoring of lipid-lowering treatment). Level I tests: determination of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides; reference values for lipids. CARDIOVASCULAR RISK Atherosclerosis: plaque formation- role of LDL/HDL cholesterol. Non lipid risk factors associated with coronary artery disease (CAD).Patient's global risk and therapeutic goals of lowering LDL-cholesterol levels to prevent cardiovascular diseases.

For a fruitful study of the subject, and for an adequate understanding of the didactic materials are required notions of general and inorganic chemistry, biochemistry and molecular biology.

M. Ciaccio, "Elementi di Biochimica Clinica e Medicina di Laboratorio", (EdiSES)

The lessons are held both face-to-face and on the Meet platform to allow the use of fragile students in the COVID emergency period

mandatory attendance

The written test consists in the administration of a questionnaire of 10 questions (multiple choice quizzes) related to the Clinical Biochemistry module. The student who has passed the written exam can access the oral exam.

The lessons are held face-to-face