Molecular Biology, Medicinal Chemistry and Computer Science for Pharmaceutical Applications

The course aims to illustrate the structure, physiology, and functions of microorganisms, as well as the mechanisms underlying genetic variability and adaptation. Particular attention is devoted to understanding the interactions between microorganisms and hosts, mechanisms of pathogenicity, and activation of the immune response. The course also covers major molecular and cellular biology techniques used to study microorganisms. Specific Objectives Knowledge and understanding By the end of the course, students will have acquired knowledge in the following areas: Structure and physiology of prokaryotic cells Principles of classification, taxonomy, diversity, and molecular evolution of microorganisms Modes of prokaryotic replication and techniques to control and measure microbial growth Mechanisms of action of major antibiotics and mechanisms of antibiotic resistance Mechanisms of pathogenicity and bacterial virulence factors Structure and replication of viruses and bacteriophages Biology of major bacterial species of clinical relevance Biology of major viruses of clinical relevance Principles of molecular and cellular biology for the study of microorganisms Applying knowledge and understanding At the end of the course, the student will be able to: Integrate the knowledge acquired in the Fundamentals of Microbiology course with that gained from other courses in the degree program; Understand the structure and physiology of microorganisms for the study of innovative applications in the field of microbiology; Understand the main mechanisms of microbial pathogenicity for the study of antimicrobial strategies; Understand and describe key technologies in the field of microbiology. Critical and judgmental skills At the end of this course, the student will be able to: Interpret experimental data from scientific articles; Formulate judgements in professional contexts and for various purposes within the field of microbiology. Communication skills At the end of this course, the student will be able to: Communicate the acquired knowledge in professional contexts and for various purposes, using appropriate language (correct use of technical and scientific terminology); Present data from scientific literature. Learning skills The student should be able to build their own path of scientific growth in a critical and independent manner, being able to correctly use the study materials provided by the instructor as well as additional resources they may find on their own. These skills will be encouraged by the instructor, as much as possible, through in-depth discussions proposed during the lessons.