THREE-DIMENSIONAL MODELING

Course objectives

General skills At the end of the course and upon passing the exam, the student will have acquired knowledge and skills on the molecular and biochemical bases associated with bacterial pathogenicity and on the mechanisms of persistence and resistance of bacteria to drugs and the immune system. This knowledge will allow the student to understand the most innovative biotechnological strategies used for the study and fight against bacterial infections. Students will learn the applications of genomic and proteomic technologies applied to the design of inhibitors of resistance and virulence mechanisms and to the innovative formulation of vaccines. Students' analytical and learning skills will be exercised through the assignment of original scientific works and reviews, used as study and personal elaboration texts in in-depth seminars organized to improve their communication, discussion and interpretation skills of original experimental data Specific skills a) knowledge and understanding knowledge of the mechanisms of action and acquisition of the factors of pathogenicity, resistance, communication and bacterial immunity; knowledge of biotechnology applied to the formulation of innovative vaccines; b) applying knowledge and understanding know how to describe and evaluate sensitivity and specificity of the methodologies of diagnostics and characterization of bacteria; ability to understand and describe the evolution of microbial biotechnologies applied to the formulation of contemporary and future generation antibacterial and antiviral vaccines; c) making judgments know how to analyze recent literature related to microbial biotechnology applications and critically reading of the results; know how to evaluate advantages and limitations of elaborates and projects in the fields of diagnostics, antibiotic resistance and vaccine development; d) communication skills to be able to illustrate and explain with appropriate terms and with scientific rigor scientific research reports and publications including aspects of medical biotechnology applied to the fight against infections; e) learning skills acquisition of the fundamentals and cognitive tools to continue independently in the deepening of microbial biotechnology; acquisition of basic knowledge to progress independently in other biological disciplines.

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ALESSANDRA CARATTOLI Lecturers' profile

Program - Frequency - Exams

Course program
Diagnostics of infections with pathogenic bacteria: cultivation and molecular methodologies and procedures, and instrumental procedures, including automated ones, based on the direct or indirect determination of the presence of the infectious agent or its constituents (nucleic antigens and acids, antibodies) Genomic analysis, phylogeny, and evolution: -Sequencing of bacterial genomes and prediction of functions from genome annotation -Functional genomics: transcriptomics and proteomics -Molecular phylogeny of microorganisms Using genomics to understand microbial pathogenicity: from commensal to pathogen: -Toxigenic factors -Ability to survive to the phagosome -Micro-host interactions, invasion, adhesion -Microbial communication systems: quorum sensing Biotechnological development lines for the formulation and production of antimicrobial and antiviral vaccines; reverse vaccinology
Prerequisites
The Course of Microbial Biotechnology takes place in the second year in the first semester.
Books
Brock- Biology of microorganisms Pearson Literature articles
Frequency
Attendance is essential for thematic seminars and presentations organized by students.
Exam mode
The ongoing assessment consists of a reverse lesson on a program topic to be presented to the class. The exam has the objective of verifying the level of knowledge and in-depth analysis of the topics of the teaching program, the reasoning skills acquired and the presentation skills. The evaluation is expressed out of thirty (minimum mark 18/30, maximum mark 30/30 with honors). The evaluation consists of an oral test consisting in the discussion of an article chosen by the candidate but approved by the teacher. Both the mark obtained in the oral test which is aimed at verifying the knowledge of the topics covered in the course and the mark of the reverse lesson made by the student during personal presentations in class contribute to the final grade. To achieve the score of 30/30 cum laude, the student must demonstrate that he has acquired excellent knowledge of the topics covered in the course and an excellent ability to explain specific and advanced topics in a clear and competent way.
Lesson mode
Lessons in class, for students not available lesson can be followed from remote
  • Academic year2025/2026
  • CourseBiochemistry
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDBIO/19
  • CFU3