Medical Biotechnology

Introduction to the adaptive immune response. Main mechanisms of immunotolerance. Aberrant immune responses in immunopathology. B lymphocyte-mediated immunopathology: main functions, tolerance mechanisms, roles of antibodies in autoimmunity. Pathogenesis of lupus and disease models. Rheumatoid arthritis pathogenesis and disease models. Immunopathology mediated by T helper lymphocytes: definition of subpopulations, polarization mechanisms, roles in autoimmunity. Pathogenesis of multiple sclerosis and related animal models. Immunoregulation and regulatory T lymphocytes: development, physiological roles, focus on the suppression of anticancer immunosurveillance. Animal models of cancer. Antiviral immunity mediated by CD8 T lymphocytes: activation mechanisms and main functions, functional exhaustion, protective effects in viral infections. Mouse models of the CD8-mediated response in viral infections.

Cellular and Molecular Immunology Abbas 9th Edition (Elsevier) Immunologia Cellulare e Molecolare Abbas Ottava Edizione (Masson)