Course program
Lesson 1 (4h) - General introduction to the course (syllabus review) - Introduction to biomaterials (evolution: 1st generation, 2nd generation, and 3rd generation; importance and main functions) - Introduction to materials science and engineering (analysis of the central paradigm of materials science and engineering) - Chemical bonds (ionic, covalent, metallic, and secondary bonds) and main classes of materials (metals, ceramics, and polymers) - Crystalline solids (main crystal structures BCC, FCC, and HCP) and amorphous solids
Lesson 2 (4h) - Imperfections in solids (0-, 1-, 2-, and 3-dimensional defects) - Mechanical properties (concepts of stress and elastic/plastic deformation, plastic deformation and dislocations in metals, methods of metal work hardening) - Introduction to material failure, fatigue testing, and creep - Electrical, thermal, and optical properties
Lesson 3 (4h) - Introduction to metallic biomaterials and alloys - Study and analysis of phase diagrams (iron-carbon diagram) - Non-ferrous alloys: titanium alloys - Overview of corrosion and biodegradable metals - Metal processing techniques
Lesson 4 (4h) - Ceramic biomaterials (mechanical properties and statistical approach for result interpretation) - Ceramic processing techniques - Bioinert ceramic biomaterials: Alumina, Zirconia, Carbon - Biodegradable or resorbable ceramic biomaterials (Tricalcium phosphate and Hydroxyapatite)
Lesson 5 (4h) - Polymeric biomaterials (general characteristics, polymerization techniques, viscoelastic and mechanical properties, thermal characteristics) - Polymer processing techniques - Biocompatible polymers - Biodegradable polymers
Lesson 6 (4h) - Composite biomaterials (general characteristics, mechanical properties) - Surface modification techniques - Course summary with proposed case studies and guided analysis for material selection, considering properties and clinical screening
Books
Biomaterials science: an introduction to materials in medicine B. D. Ratner, A. S. Hoffman, et al., Academic Press, 3rd ed., 2012
Bibliography
Teaching materials and sources available in scientific databases provided/recommended by the instructor.
