Biomedical Engineering

1. Introduction to Metallic Materials for Biomedical Applications. Fundamentals of metallic biomaterials, biocompatibility, and corrosion in physiological environments. 2. Microstructure and Properties of Metallic Materials. Crystalline structures and defects in metals. 3. Diffusion in Solids 4. Phase Diagrams (Metal Alloys) 5. Main Classes of Metallic Materials Used in Biomedical Applications: stainless steels, titanium and its alloys, shape memory alloys, cobalt-based alloys, and magnesium alloys. 6. Corrosion in Physiological Environments (Overview) 7. Surface Modifications for Biomedical Applications 8. Surface Treatments Using Radiation, Plasma Processes, and Etching Techniques 9. Polymeric Coatings via Grafting Techniques and Controlled Surface Polymerization 10. Techniques for Biomolecule Immobilization and Bioconjugation Strategies (Click Chemistry) 11. Surface Patterning 12. Laboratory Demonstrations

Students are expected to have a basic knowledge of chemistry and physics

• Ratner B. D., Hoffman A. S., et al., “Biomaterials Science: An Introduction to Materials in Medicine”, 3rd Ed., Academic Press, 2012 • Di Bello C., Bagno A., “Biomateriali. Dalla Scienza dei Materiali alle Applicazioni Cliniche”, 2nd Ed., Patron Editore, 2016

not mandatory

The oral exam will aim to verify the state of knowledge and ability of critical analysis of the topics covered during the lectures. The evaluation will be performed as follows (scores on a scale of 18-30): minimal knowledge (18-20); medium knowledge (21-23); sufficient knowledge and ability to apply it (24-25); good knowledge and ability to apply it (26-28); excellent knowledge and ability to apply it with good communication skills and critical thinking (29-30).

Lecture notes/slides by the instructor

Lessons in classroom