GENETICS

Course objectives

Educational goals The aims of the course are to i) spread the fundamental principles of classical genetics; and to ii) to highlight the enormous impact of genetics in different fields of our life and the conceptual and the practical consequences derived from the use of genetic method and mutational analysis. The students will be provided with theoretical and methodological bases useful to deepen their undestanding of biological systems. The acquired knowledge will allow the students to tackle more complex issues such as: i) the structural and functional analyses of eukaryotic genomes, ii) the study of global gene expression in animals and plants, iii) the methodologies of genome editing and gene therapy. An further educational goal of the Genetics course is to provide, through laboratory experience, the skills to be able to intervene critically on ethical and social aspects related to the use of modern genetic approaches for treatment of diseases. The knowledge and skills acquired are necessary for continuing the training in Biotechnology. Students who pass the examination will be able to know and understand: - The genetic basis of heredity - The relationships between genotype and phenotype - The complex mechanisms of gene regulation in differentiation and development - The organization and functions of eukaryotic genomes - The contents of a scientific article on Genetics

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PATRIZIO DIMITRI Lecturers' profile

Program - Frequency - Exams

Course program
Mendel’s laws. Mendelian inheritance in humans. The chromosomal theory of heredity. Genetic linkage and crossing-over. Recombination in bacteria and viruses. DNA structure and replication. Identification, study and classification of mutations. Nature and function of genes. Control of gene expression in procaryotes and eukaryotes. Structure and function of eukaryotic genomes. Genes and development. Population genetics. Classroom exercises: Problems of Mendelian genetics applied to plant and animal organisms. Examples referring to cases of hereditary transmission of human genetic diseases. Laboratory exercises: introduction to the materials and methods of the Genetics and Cytogenetics of Drosophila melanogaster.
Prerequisites
Basic knowledge of Biology
Books
One chosen from the following books: 1. Goldberg, Genetica. Ed. Mac Graw-Hill (2022) 2. Griffiths - Doebley - Peichel - Wassarman , Genetica . Principi di analisi formale . (2021) 3. Pierce, Genetica. Ed. Zanichelli (2016) 4. Genetica, Casa Editrice Ambrosiana (2014)
Frequency
Attendance to the lessons is not mandatory, but it is recommended.
Exam mode
The exam test is aimed at verifying the level of understanding and in-depth study of program and the reasoning skills that the students have developed during the course. The evaluation is expressed in thirtieths (minimum mark 18/30, maximum mark 30/30 with honors). The exam consists of an oral interview made up of some questions. The student can discuss and deepen a topic chosen from those present in the program. Overall, the exam allows the teacher to verify the achievement of the objectives in terms of knowledge and skills acquired by the student, as well as the critical skills and the scientific language.
Bibliography
No bigliography
Lesson mode
The course is organized in theoretical lessons and exercises. In particular, a total of 76 teaching hours (9 CFU) are scheduled, of which 64 hours of frontal lessons (8CFU) and 12 hours of exercises (1 CFU). The lessons are held weekly in the classroom through the use of slides on power-points and projection of didactic videos. The exercises will be both numerical on the blackboard and practical in the laboratories.There will be a two-hour written test focused on topics related to the first 2/3 of the course program which will include 4 exercises. The test will take place in the classroom and the teacher will take care of the correction by interacting directly with the students and giving them the opportunity to further verify the preparation.
  • Lesson code1011788
  • Academic year2024/2025
  • CourseFood and Industrial Biotechnology
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDBIO/18
  • CFU9
  • Subject areaDiscipline biotecnologiche comuni