THREE-DIMENSIONAL MODELING

Course objectives

The main objective of the course is to provide students with the basics to address the study and understanding of the mechanisms underlying the control of gene expression that act at different levels, transcriptional, post-transcriptional, translational and post-translational. The main objective of the course is to provide students with the basics to address the study and understanding of the complex molecular mechanisms responsible for the structure and expression of the genome. Knowledge and understanding The student: - Knows the correct terminology of molecular biology; - Knows the molecular bases of biological systems and processes; - Know the mechanisms and the different levels of gene expression regulation, and their integration; -It knows the basic techniques for the study of nucleic acids Ability to apply knowledge and understanding The student: - knows how to correctly use molecular biology terminology; - will be able to orientate itself in the understanding and design of approaches to modulation of gene expression for therapeutic or biotechnological purposes; - is able to use the knowledge on techniques for the study of nucleic acids to design an experiment in research.

Channel 1
ALESSANDRO FATICA Lecturers' profile

Program - Frequency - Exams

Course program
1. Imprinting and X chromosome dosage compensation 2. RNA quality control ("Non-sense mediated decay", "non stop decay" and "no GO decay") 3. RNA export 4. mRNA Degradation 5. Translational control 6. RNA modifications and regulation of gene expression 7. RNA editing
Prerequisites
Prerequisites are not foreseen. The student must however have basic knowledge of molecular biology, with particular attention to eukaryotes, and basic notions of genetic engineering, with properties of language.
Books
Reviews and lessons available on http://elearning2.uniroma1.it/ Francesco Amaldi, Piero Benedetti, Graziano Pesole, Paolo Plevani TECNICHE E METODI PER LA BIOLOGIA MOLECOLARE ZANICHELLI
Frequency
Classroom lectures (not mandatory but highly recommended)
Exam mode
Knowledge of the contents of the scientific works discussed and ability to report problems faced in class. Learning of regulatory processes and methodologies of the discipline. Connection capacity between the various biological processes analyzed. Ability to reprocess the acquired knowledge in a personal and critical way. Expressive properties of use, in particular, of specialized terminology.
Lesson mode
Frontal lessons with ppt presentations
  • Academic year2025/2026
  • CourseGenetics and Molecular Biology
  • CurriculumGenetica e Biologia Molecolare (percorso valido anche ai fini del conseguimento del doppio titolo italo-francese)
  • Year1st year
  • Semester2nd semester
  • SSDBIO/11
  • CFU6