THREE-DIMENSIONAL MODELING

Course objectives

General skills Provide the knowledge of the main biochemical methods for analysing of the properties of a protein from its isolation to its structural and functional characterization with particular focus on proteins involved in neurodegenerative processes. Skills module I Knowledge of the main biochemical methods for analysis of the structural and functional properties of proteins Skills module II Knowledge of the biochemical properties of specific proteins involved in neurodegenerative processes. Specific skills (common to both modules) A) knowledge and understanding The student: - Knows the main techniques necessary for the biochemical characterization of proteins; - Knows the main proteins involved in neurodegenerative diseases B) ability to apply knowledge and understanding The student is able to: - understand and evaluate the impact of structural modifications of biological macromolecules on their biological function; - exploit the knowledge of biochemical techniques to investigate the role of proteins involved in neurodegeneration C) Making judgements - critical thinking through the study of biochemical methods and their application to structural and functional analysis of proteins - learning by questioning D) Communication skills The student is able to: -communicate what has been learned during the oral exam E) Learning skills - learning the specific terminology - be able to make the logical connections between the topics covered - be able to identify the most relevant topics

Channel 1
MARIA CARMELA BONACCORSI DI PATTI Lecturers' profile

Program - Frequency - Exams

Course program
Biochemical methods for production of recombinant proteins Advanced spectroscopic methods for protein studies Biochemical methods for qualitative and quantitative analysis of macromolecular interactions Biophysical methods applied to the study of protein–protein interactions Genetic methods applied to the study of protein-protein interactions
Prerequisites
No formal propedeuticity is required. However, basic knowledge of biochemistry, molecular biology as well as of cellular biology is necessary.
Books
Text books and other materials are promptly published at the educational site Elearning2 at http://elearning2.uniroma1.it
Teaching mode
classroom lectures and guided activities in the laboratory
Frequency
Lectures and guided activities are not mandatory.
Exam mode
The aim of the exam is to test the level of knowledge and deepening of the topics of the course program and the reasoning skills developed by the student on issues related to biochemical methods. The assessment is expressed in thirtieths (minimum grade 18). The exam is oral and the answers to the questions are evaluated both for the content and for the appropriate scientific language.
Lesson mode
classroom lectures and guided activities
  • Academic year2025/2026
  • CourseNeurobiology
  • CurriculumSingle curriculum
  • Year1st year
  • Semester2nd semester
  • SSDBIO/10
  • CFU3