THREE-DIMENSIONAL MODELING

Course objectives

General Skills. The teaching course will be held with lectures and supplemented by thematic seminars coordinated by the teacher for highly specific topics. The course aims to develop the following skills: -Knowledge of the structure and function of the main classes of nanovectors, the limitation on the formulations and of the production of the nanovectors; -Knowledge the relationship between physical-chemical properties and applications of the nanocarrier; -Knowledge and understanding of the various methodologies to properly characterize the physical-chemical properties of the nanocarrier; -Knowledge and understanding of the various active substances used to functionalize nanocarrier surface to perform active and passive targeting; -Knowledge and understanding of the most appropriate nanocarrier to select on the basis of the nature of active loaded molecules and the field of application. Specific skills. a) knowledge and understanding - Knowledge and understanding of the relationship between structure and function of the main classes of nanocarriers and their physical-chemical properties; - knowledge of the main techniques for their characterization; - knowledge of the active compounds and their surface functionalization for the targeted delivery by using active or passive strategy; - knowledge of the limits depending on the biochemical structure of the active ingredient regarding to its field of application underlying the main properties influencing the choice of the nanocarrier; b) applying knowledge and understanding - ability to select and explain the proper formulation of the nanocarrier depending on the nature of the substance and its field of application; - ability to select appropriate techniques for nanocarrier characterization; c) making judgments - be able to solve delivery problems; - be able to identify biological and biomedical barriers related to the administration route or the field of application and therefore to select the most appropriate carrier; d) communication skills - be able to illustrate and explain the main nanocarriers with appropriate terms and with logical rigor; - be able to explain the main methodologies of characterization in general; - be able to describe targeting strategies and the field of application of the nanocarrier; e) learning skills - acquisition of the fundamentals and cognitive tools to continue independently in the study of nanotechnology; - acquisition of the basic knowledge necessary to progress autonomously in other biological and technological disciplines; - ability to learn quickly and apply nanobiotechnology techniques in various working environments.

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CARLOTTA MARIANECCI Lecturers' profile

Program - Frequency - Exams

Course program
Drug delivery and targeting: general considerations. Obstacles and advantages of nanocarrier application in: oral, pulmonary, parenteral, nasal, ocular, brain, dermal and transdermal drug delivery. Designing suitable nanocarriers for drug delivery, targeting and diagnostics. Personalized medicine. Nanotoxicological considerations. Interactions of Nanocarriers and Biosystems
Prerequisites
The student must possess: (a)good command of specific technical terminology. b)mastery of elementary algebra (properties of logarithms, operations with numbers in scientific notation, fractions and percentages) of elementary geometry and trigonometry. c)In order to understand the contents of the lectures and to achieve the learning objectives, it is necessary for the student to have acquired and assimilated the basic concepts related to a course in Organic Chemistry, Biochemistry, Physiology and Pathology (units of concentration, conversion operations of the main units of measurement, definition and units of the main physical quantities colligative properties, effect of pH and ionization, buffer systems, formulas and structures of organic substances, general aspects of organic reactions).
Books
In addition to the texts recommended below, some of which can be consulted as ebooks, and the slides projected during the course, recently published supplementary scientific material will be provided to propose updates on the topics covered. 1) Nanomedicine for drug delivery and therapeutics, Edited by Ajay Kumar Mishra, Wiley 2013. 2) Nanoscience and Nanotechnology for Human Health, Edited by Bert Muller and Marcel Van de Voorde, Wiley, 2017 3) Pharmaceutical Nanotechnology Edited by Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de Voorde, Wiley, 2017
Frequency
The lectures will be conducted face-to-face.
Exam mode
Nanotechnology teaching is divided into two modules. The examination, which takes place at the end of the teaching, is oral and will take place on the same day for the two modules. Each test consists of an interview conducted by the module lecturer so that, overall, all parts of the program are discussed. For the Drug Delivery and Targeting Strategies module, the ability to connect different aspects covered during the course will be assessed: in particular, the student will have to demonstrate to recognize and classify nanocarriers; know their formulation and manufacturing issues; and understand the relationships existing between nanocarrier technological properties, and biopharmaceutical and pharmacokinetic properties according to the chosen route of administration. To pass the test, a score of 18/30 must be acquired by demonstrating basic knowledge and skills of the topics related to nanocarrier formulation based on the intended delivery or targeting. On the other hand, to achieve a score of 30/30 cum laude, the student must demonstrate excellent knowledge of all the topics covered in the course, being able to connect them in a logical and coherent manner. Each of the lecturers, based on the criteria outlined, gives a grade in thirtieths. The final grade is an average of the two grades
Lesson mode
Lectures will be carried out frontally in the classroom. At the beginning of the lesson, what was done in the previous lesson will be summarized, and at the end of the lesson, what was explained will be summarized. During the lecture, students will be invited to ask questions by adopting a flipped classroom mode.
CARLOTTA MARIANECCI Lecturers' profile

Program - Frequency - Exams

Course program
Drug delivery and targeting: general considerations. Obstacles and advantages of nanocarrier application in: oral, pulmonary, parenteral, nasal, ocular, brain, dermal and transdermal drug delivery. Designing suitable nanocarriers for drug delivery, targeting and diagnostics. Personalized medicine. Nanotoxicological considerations. Interactions of Nanocarriers and Biosystems
Prerequisites
The student must possess: (a)good command of specific technical terminology. b)mastery of elementary algebra (properties of logarithms, operations with numbers in scientific notation, fractions and percentages) of elementary geometry and trigonometry. c)In order to understand the contents of the lectures and to achieve the learning objectives, it is necessary for the student to have acquired and assimilated the basic concepts related to a course in Organic Chemistry, Biochemistry, Physiology and Pathology (units of concentration, conversion operations of the main units of measurement, definition and units of the main physical quantities colligative properties, effect of pH and ionization, buffer systems, formulas and structures of organic substances, general aspects of organic reactions).
Books
In addition to the texts recommended below, some of which can be consulted as ebooks, and the slides projected during the course, recently published supplementary scientific material will be provided to propose updates on the topics covered. 1) Nanomedicine for drug delivery and therapeutics, Edited by Ajay Kumar Mishra, Wiley 2013. 2) Nanoscience and Nanotechnology for Human Health, Edited by Bert Muller and Marcel Van de Voorde, Wiley, 2017 3) Pharmaceutical Nanotechnology Edited by Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de Voorde, Wiley, 2017
Frequency
The lectures will be conducted face-to-face.
Exam mode
Nanotechnology teaching is divided into two modules. The examination, which takes place at the end of the teaching, is oral and will take place on the same day for the two modules. Each test consists of an interview conducted by the module lecturer so that, overall, all parts of the program are discussed. For the Drug Delivery and Targeting Strategies module, the ability to connect different aspects covered during the course will be assessed: in particular, the student will have to demonstrate to recognize and classify nanocarriers; know their formulation and manufacturing issues; and understand the relationships existing between nanocarrier technological properties, and biopharmaceutical and pharmacokinetic properties according to the chosen route of administration. To pass the test, a score of 18/30 must be acquired by demonstrating basic knowledge and skills of the topics related to nanocarrier formulation based on the intended delivery or targeting. On the other hand, to achieve a score of 30/30 cum laude, the student must demonstrate excellent knowledge of all the topics covered in the course, being able to connect them in a logical and coherent manner. Each of the lecturers, based on the criteria outlined, gives a grade in thirtieths. The final grade is an average of the two grades
Lesson mode
Lectures will be carried out frontally in the classroom. At the beginning of the lesson, what was done in the previous lesson will be summarized, and at the end of the lesson, what was explained will be summarized. During the lecture, students will be invited to ask questions by adopting a flipped classroom mode.
  • Academic year2025/2026
  • CourseNeurobiology
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDCHIM/09
  • CFU3