MATTIA LAFFRANCHI

Education
- 2012 University of Brescia, Italy. Bachelor's Degree in Biotechnologies
- 2015 University of Brescia, Italy. Master's Degree in Medical Biotechnologies
- 2019 University of Brescia, Italy. PhD in Medical Genetics, Biotechnology and Experimental Medicine

Academic Appointments
- 01/04 - 30/09/2015 University of Brescia, Italy. Research fellowship
- 01/11/2015 - 31/10/2018 University of Brescia, Italy. PhD Student
- 01/01 - 31/12/2019 University of Brescia, Italy. Postdoctoral fellowship
- 01/03/2020 - 28/02/2021 University of Brescia, Italy. Postdoctoral fellowship
- 01/03/2021 - 26/07/2023 University of Rome La Sapienza, Italy. FIRC research fellowship
- 27/07/2023 - 31/11/2025 University of Rome La Sapienza, Italy. Fixed-term researcher (RTDA)
- 01/12/2025 - Ongoing University of Rome La Sapienza, Italy. Tenure-track researcher (RTT)

Research experience abroad
01/02 - 31/06/2018 University College London (UCL), UK. Visiting PhD Student
01/03 - 30/09/2019 University College London (UCL), UK. Visiting postdoctoral fellow

Teaching experience
- 2025 University of Rome La Sapienza, Italy. General Pathology, Academic year 2025-26, Faculty of Medicine and Odontoiatry Degree in physiotherapy “H” , detachment of Bracciano.
- 2024 University of Rome La Sapienza, Italy. PhD lecture titled “The role of atypical chemokine receptors in inflammatory responses”.
- 2021 - ongoing University of Rome La Sapienza, Italy. Relator or co-relator of Bachelor thesis in Bioinformatics (L-2).
- 2023 - ongoing University of Rome La Sapienza, Italy. Co-relator of Master thesis in Medical Biotechnologies (L-9).

Society memberberships
- 2021 – ongoing Regular member SIICA (Italian Society of Immunology, Clinical Immunology and Allergology)
- 2022 - ongoing Regular member SIPMeT (Italian Society of Pathology and Translational Medicine)
- 2021 - 2024 Faculty member SIICA Junior Board
- 2024 - ongoing Faculty member SIICA Junior Board

Funding Information
2021 – 23 AIRC FIRC fellowship “Licia Venditti e Antonio D’Orazio” (ID25307), 90.000 €

Summary of Scientific Achievements
Papers [international] 29 (Scopus, from 2017)
Total Impact factor 246
Total Citations 971
Average Citations per Product 33.5
Hirsch (H) index 14

Selected Publications
- Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK cell infiltration and plasticity. Russo E, D'Aquino C, Di Censo C, Laffranchi M, Tomaipitinca L, Licursi V, Garofalo S, Promeuschel J, Peruzzi G, Sozio F, Kaffke A, Garlanda C, Panzer U, Limatola C, Vosshenrich CA, Sozzani S, Sciumè G, Santoni A, Bernardini G. J Clin Invest. 2025 Apr 1;135(11):e184036. doi: 10.1172/JCI184036.
- Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity. Laffranchi M, Paraboschi EM, Bianchetto-Aguilera F, Tamassia N, Gasperini S, Gardiman E, Piserà A, Del Prete A, Invernizzi P, Gismondi A, Mantovani A, Cassatella MA, Asselta R, Sozzani S. Heliyon. 2024 Dec 17;11(1):e41267. doi: 10.1016/j.heliyon.2024.e41267.
- Chemerin in immunity. Laffranchi M, Schioppa T, Sozio F, Piserà A, Tiberio L, Salvi V, Bosisio D, Musso T, Sozzani S, Del Prete A. J Leukoc Biol. 2024 Sep 4:qiae181. doi: 10.1093/jleuko/qiae181.
-CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer. Sozio F, Schioppa T, Laffranchi M, Salvi V, Tamassia N, Bianchetto-Aguilera FM, Tiberio L, Bonecchi R, Bosisio D, Parmentier M, Bottazzi B, Leone R, Russo E, Bernardini G, Garofalo S, Limatola C, Gismondi A, Sciumè G, Mantovani A, Del Prete A, Sozzani S. Cancer Immunol Res. 2023 Sep 1;11(9):1280-1295.
- Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti A.M, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks S.R, Tsai W.L, Mikami Y, Bernardini G, Gismondi A, Sozzani S, Di Santo J.P, Vosshenrich C.A.J, Diefenbach A, Gadina M, Santoni A, Sciumè G. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2306761120.
- Dendritic cell subsets in cancer immunity and tumor antigen sensing. Del Prete A, Salvi V, Soriani A, Laffranchi M, Sozio F, Bosisio D, Sozzani S. Cell Mol Immunol. 2023 Mar 22. doi: 10.1038/s41423-023-00990-6.
- SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8. Salvi V, Nguyen HO, Sozio F, Schioppa T, Gaudenzi C, Laffranchi M, Scapini P, Passari M, Barbazza I, Tiberio L, Tamassia N, Garlanda C, Del Prete A, Cassatella MA, Mantovani A, Sozzani S, Bosisio D. JCI Insight. 2021 Sep 22;6(18):e150542.

Editorial activities
2026 – Ongoing Cytokine (ISSN: 1096-0023), Social Media Editor
2026 – Ongoing Frontiers in Immunology (ISSN 1664-3224), section Cytokines and Soluble Mediators in Immunity, Associate Editor
2025 – Ongoing Immunobiology (ISSN: 1878-3279) Young Investigator Board
2024 - 2025 Immunobiology (ISSN: 1878-3279), Social Media Editor