Medicine and Surgery

In order to be able to understand the teaching content and achieve the learning objectives, at the beginning of the activities in the teaching module the student must have basic knowledge of biology, genetics, histology, anatomy, biochemistry and physiology

mandatory

oral examination

lectures

• Definition of general Pathology. Health status and pathological manifestations. Etiology and pathogenesis. Evolution, course and outcomes of disease. • Environmental pathology. Pathology from physical agents (radiant energy, thermal energy, electrical energy, mechanical energy). Pathology from chemical agents. Biological agents as a cause of disease. Congenital nonhereditary pathology. Teratogenesis. • Genetic pathology: Gene mutation pathology. Patterns of hereditary transmission in genetic diseases. Patterns of human genetic diseases. Major human diseases from karyotype abnormalities. Methods of studying genetic diseases (chromosomal, gene and proteomic analysis). • Molecular pathology: Molecular pathology of proteins. Hemoglobinopathies. Molecular pathology Noncoding RNAs, histone modifications and DNA methylation. Enzyme deficiency pathology. Molecular pathology receptor, channel, mitochondrial and transduction mechanisms. Animal and cellular models of disease. • Pathology of cellular structures: Cell response to damage: cellular stress, cellular adaptations (hypertrophy, hyperplasia, atrophy, metaplasia). Molecular mechanisms of cellular damage. Mechanisms of cell death. Intracellular accumulation (steatosis, glycogenosis, lysosomal diseases). Aging. Pathology of heme metabolism • Pathologies of the extracellular matrix: Beta-fibrillosis. Localized and systemic fibrosis. Diseases of collagen and other basement membrane components. Prion diseases. • Inflammation: generalities on inflammation: acute (angiophlogosis) and chronic (histophlogosis) inflammation; Receptors of innate immunity and inflammation. Cells of inflammation. Chemical mediators of inflammation. Mechanisms of exudate formation and types of exudate. Chronic nongranulomatous inflammation and chronic granulomatous inflammation. Mechanisms of granuloma formation. Foreign body granulomas. Immunologic granulomas. Systemic manifestations of inflammation. Regulation of the inflammatory process. Repair process. • Pathophysiology of thermoregulation: febrile and nonfebrile hyperthermias, hypothermias.

A basic knowledge of biochemistry, biology and genetics, human histology and embryology, microbiology, human anatomy and physiology is required. To take the final exam (including the I and II semester), the student must have passed all the exams of the I and II years and Human Physiology. It is not necessary to have completed the Human Physiology exam to take the eligibility (only I semester topics).

Pontieri – Mainiero – Misasi – Sorice. Patologia generale e fisiopatologia generale – Volumi 1 e 2 ed. Piccin, VI edizione 2018 Robbins e Cotran. Le basi patologiche delle malattie. Patologia generale cofanetto (ed. 2021) ed. EDRA

Mandatory

Oral examination

Frontal lectures

• Definition of general Pathology. Health status and pathological manifestations. Etiology and pathogenesis. Evolution, course and outcomes of disease. • Environmental pathology. Pathology from physical agents (radiant energy, thermal energy, electrical energy, mechanical energy). Pathology from chemical agents. Biological agents as a cause of disease. Congenital nonhereditary pathology. Teratogenesis. • Genetic pathology: Gene mutation pathology. Patterns of hereditary transmission in genetic diseases. Patterns of human genetic diseases. Major human diseases from karyotype abnormalities. Methods of studying genetic diseases (chromosomal, gene and proteomic analysis). • Molecular pathology: Molecular pathology of proteins. Hemoglobinopathies. Molecular pathology Noncoding RNAs, histone modifications and DNA methylation. Enzyme deficiency pathology. Molecular pathology receptor, channel, mitochondrial and transduction mechanisms. Animal and cellular models of disease. • Pathology of cellular structures: Cell response to damage: cellular stress, cellular adaptations (hypertrophy, hyperplasia, atrophy, metaplasia). Molecular mechanisms of cellular damage. Mechanisms of cell death. Intracellular accumulation (steatosis, glycogenosis, lysosomal diseases). Aging. Pathology of heme metabolism • Pathologies of the extracellular matrix: Beta-fibrillosis. Localized and systemic fibrosis. Diseases of collagen and other basement membrane components. Prion diseases. • Inflammation: generalities on inflammation: acute (angiophlogosis) and chronic (histophlogosis) inflammation; Receptors of innate immunity and inflammation. Cells of inflammation. Chemical mediators of inflammation. Mechanisms of exudate formation and types of exudate. Chronic nongranulomatous inflammation and chronic granulomatous inflammation. Mechanisms of granuloma formation. Foreign body granulomas. Immunologic granulomas. Systemic manifestations of inflammation. Regulation of the inflammatory process. Repair process. • Pathophysiology of thermoregulation: febrile and nonfebrile hyperthermias, hypothermias.

Prerequisites A basic knowledge of biochemistry, biology and genetics, human histology and embryology, microbiology, human anatomy and physiology is required. To take the final exam (including the I and II semester), the student must have passed all the exams of the I and II years and Human Physiology. It is not necessary to have completed the Human Physiology exam to take the eligibility (only I semester topics).

Adopted tests: Pontieri – Mainiero – Misasi – Sorice. Patologia generale e fisiopatologia generale – Volumi 1 e 2 ed. Piccin, VI edizione 2018 Robbins e Cotran. Le basi patologiche delle malattie. Patologia generale cofanetto (ed. 2021) ed. EDRA

Attendance is mandatory. To be admitted to the exam, 67% of attendance is required for all lessons of the course

frontal lessons

• Definition of general Pathology. Health status and pathological manifestations. Etiology and pathogenesis. Evolution, course and outcomes of disease. • Environmental pathology. Pathology from physical agents (radiant energy, thermal energy, electrical energy, mechanical energy). Pathology from chemical agents. Biological agents as a cause of disease. Congenital nonhereditary pathology. Teratogenesis. • Genetic pathology: Gene mutation pathology. Patterns of hereditary transmission in genetic diseases. Patterns of human genetic diseases. Major human diseases from karyotype abnormalities. Methods of studying genetic diseases (chromosomal, gene and proteomic analysis). • Molecular pathology: Molecular pathology of proteins. Hemoglobinopathies. Molecular pathology Noncoding RNAs, histone modifications and DNA methylation. Enzyme deficiency pathology. Molecular pathology receptor, channel, mitochondrial and transduction mechanisms. Animal and cellular models of disease. • Pathology of cellular structures: Cell response to damage: cellular stress, cellular adaptations (hypertrophy, hyperplasia, atrophy, metaplasia). Molecular mechanisms of cellular damage. Mechanisms of cell death. Intracellular accumulation (steatosis, glycogenosis, lysosomal diseases). Aging. Pathology of heme metabolism • Pathologies of the extracellular matrix: Beta-fibrillosis. Localized and systemic fibrosis. Diseases of collagen and other basement membrane components. Prion diseases. • Inflammation: generalities on inflammation: acute (angiophlogosis) and chronic (histophlogosis) inflammation; Receptors of innate immunity and inflammation. Cells of inflammation. Chemical mediators of inflammation. Mechanisms of exudate formation and types of exudate. Chronic nongranulomatous inflammation and chronic granulomatous inflammation. Mechanisms of granuloma formation. Foreign body granulomas. Immunologic granulomas. Systemic manifestations of inflammation. Regulation of the inflammatory process. Repair process. • Pathophysiology of thermoregulation: febrile and nonfebrile hyperthermias, hypothermias.

A basic knowledge of biochemistry, biology and genetics, human histology and embryology, microbiology, human anatomy and physiology is required. To take the final exam (including the I and II semester), the student must have passed all the exams of the I and II years and Human Physiology. It is not necessary to have completed the Human Physiology exam to take the eligibility (only I semester topics).

Pontieri – Mainiero – Misasi – Sorice. Patologia generale e fisiopatologia generale – Volumi 1 e 2 ed. Piccin, VI edizione 2018 Robbins e Cotran. Le basi patologiche delle malattie. Patologia generale cofanetto (ed. 2021) ed. EDRA

attendance is mandatory

oral test on topics covered during lectures

frontal lectures